0 152

Cited 25 times in

Inhibition of connexin 43 alters Shh and Bmp-2 expression patterns in embryonic mouse tongue

Authors
 Jae-Young Kim  ;  Sung-Won Cho  ;  Min-Jung Lee  ;  Heui-Jung Hwang  ;  Jong-Min Lee  ;  Syng-Ill Lee  ;  Takashi Muramatsu  ;  Masaki Shimono  ;  Han-Sung Jung 
Citation
 CELL AND TISSUE RESEARCH, Vol.320(3) : 409-415, 2005 
Journal Title
 CELL AND TISSUE RESEARCH 
ISSN
 0302-766X 
Issue Date
2005
MeSH
Connexin 43 ; Fungiform papilla ; Shh ; Bmp-2 ; Antisense-oligodeoxynucleotide ; Mouse (ICR)
Keywords
Connexin 43 ; Fungiform papilla ; Shh ; Bmp-2 ; Antisense-oligodeoxynucleotide ; Mouse (ICR)
Abstract
The morphogenesis of fungiform papillae occurs in a stereotyped pattern on the dorsal surface of the mammalian tongue via epithelial–mesenchymal interactions. These interactions are thought to be achieved via intercellular communication. Gap junctions can be observed in many developing tissues and have been suggested to participate in a variety of functions, including the regulation of cell proliferation, differentiation, and apoptosis. Here, we demonstrate that the expression of Connexin 43 (Cx43), a gap junction protein, is correlated significantly with the development of fungiform papillae, which exhibit a pattern formation and morphogenesis similar to the development of other epithelial appendages. Antisense-oligodeoxynucleotide (AS-ODN) against Cx43 was used to assess the developmental functions of Cx43. The expression patterns of the signaling molecules were disrupted by Cx43 inhibition. Interestingly, the expression patterns of Shh, a key molecule in the determination of the spacing patterns of fungiform papillae, were disturbed after treatment with Cx43 AS-ODN. We have also attempted to determine the functions of Bmp-2 by applying NOGGIN protein to tongue cultures. Our results indicate that upstream regulation via Cx43 controls the Shh and Bmp-2 pathways for the morphogenesis and pattern formation of fungiform papillae.
Full Text
http://link.springer.com/article/10.1007%2Fs00441-005-1091-y
DOI
10.1007/s00441-005-1091-y
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Lee, Syng Ill(이승일)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147303
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse