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Inhibition of connexin 43 alters Shh and Bmp-2 expression patterns in embryonic mouse tongue
DC Field | Value | Language |
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dc.contributor.author | 김재영 | - |
dc.contributor.author | 이승일 | - |
dc.contributor.author | 이종민 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2017-05-04T07:26:55Z | - |
dc.date.available | 2017-05-04T07:26:55Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0302-766X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147303 | - |
dc.description.abstract | The morphogenesis of fungiform papillae occurs in a stereotyped pattern on the dorsal surface of the mammalian tongue via epithelial–mesenchymal interactions. These interactions are thought to be achieved via intercellular communication. Gap junctions can be observed in many developing tissues and have been suggested to participate in a variety of functions, including the regulation of cell proliferation, differentiation, and apoptosis. Here, we demonstrate that the expression of Connexin 43 (Cx43), a gap junction protein, is correlated significantly with the development of fungiform papillae, which exhibit a pattern formation and morphogenesis similar to the development of other epithelial appendages. Antisense-oligodeoxynucleotide (AS-ODN) against Cx43 was used to assess the developmental functions of Cx43. The expression patterns of the signaling molecules were disrupted by Cx43 inhibition. Interestingly, the expression patterns of Shh, a key molecule in the determination of the spacing patterns of fungiform papillae, were disturbed after treatment with Cx43 AS-ODN. We have also attempted to determine the functions of Bmp-2 by applying NOGGIN protein to tongue cultures. Our results indicate that upstream regulation via Cx43 controls the Shh and Bmp-2 pathways for the morphogenesis and pattern formation of fungiform papillae. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | CELL AND TISSUE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Connexin 43 | - |
dc.subject.MESH | Fungiform papilla | - |
dc.subject.MESH | Shh | - |
dc.subject.MESH | Bmp-2 | - |
dc.subject.MESH | Antisense-oligodeoxynucleotide | - |
dc.subject.MESH | Mouse (ICR) | - |
dc.title | Inhibition of connexin 43 alters Shh and Bmp-2 expression patterns in embryonic mouse tongue | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.department | Dept. of Oral Biology, Oral Science Research Center | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jae-Young Kim | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Min-Jung Lee | - |
dc.contributor.googleauthor | Heui-Jung Hwang | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Takashi Muramatsu | - |
dc.contributor.googleauthor | Masaki Shimono | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1007/s00441-005-1091-y | - |
dc.contributor.localId | A00862 | - |
dc.contributor.localId | A02924 | - |
dc.contributor.localId | A04640 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03837 | - |
dc.relation.journalcode | J00474 | - |
dc.identifier.eissn | 1432-0878 | - |
dc.identifier.pmid | 10.1007/s00441-005-1091-y | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00441-005-1091-y | - |
dc.subject.keyword | Connexin 43 | - |
dc.subject.keyword | Fungiform papilla | - |
dc.subject.keyword | Shh | - |
dc.subject.keyword | Bmp-2 | - |
dc.subject.keyword | Antisense-oligodeoxynucleotide | - |
dc.subject.keyword | Mouse (ICR) | - |
dc.contributor.alternativeName | Kim, Jae Young | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.alternativeName | Lee, Jong Min | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.citation.volume | 320 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 409 | - |
dc.citation.endPage | 415 | - |
dc.identifier.bibliographicCitation | CELL AND TISSUE RESEARCH, Vol.320(3) : 409-415, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48476 | - |
dc.type.rims | ART | - |
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