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Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults: A cross-sectional study

 Ji Young Kim  ;  Choae Lee  ;  Minsuk Oh  ;  Jee-Aee Im  ;  Ji-Won Lee  ;  Sang Hui Chu  ;  Hyangkyu Lee  ;  Justin Y. Jeon 
 Clinica Chimica Acta, Vol.458 : 12-17, 2016 
Journal Title
 Clinica Chimica Acta 
Issue Date
Adiposity ; Blood Glucose/analysis ; Cross-Sectional Studies ; Female ; Humans ; Insulin Resistance* ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood* ; Non-alcoholic Fatty Liver Disease/epidemiology ; Obesity/blood ; Obesity/epidemiology ; Prevalence ; Republic of Korea
Insulin resistance ; Metabolic syndrome ; Non-alcoholic fatty liver disease
BACKGROUND: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. METHODS: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. RESULTS: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). CONCLUSIONS: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
이향규(Lee, Hyang Kyu) ORCID logo https://orcid.org/0000-0002-0821-6020
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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