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Evaluation of Underlying Lymphocytic Thyroiditis With Histogram Analysis Using Grayscale Ultrasound Images

 Ga Ram Kim  ;  Eun-Kyung Kim  ;  Soo Jin Kim  ;  Eun Ju Ha  ;  Jaeheung Yoo  ;  Hye Sun Lee  ;  Jung Hwa Hong  ;  Jung Hyun Yoon  ;  Hee Jung Moon  ;  Jin Young Kwak 
 Journal of Ultrasound in Medicine, Vol.35(3) : 519-526, 2016 
Journal Title
 Journal of Ultrasound in Medicine 
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms* ; Data Interpretation, Statistical* ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods* ; Machine Learning* ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Sensitivity and Specificity ; Thyroiditis, Autoimmune/diagnostic imaging* ; Ultrasonography/methods* ; Young Adult
head and neck ultrasound ; histogram analysis ; lymphocytic thyroiditis ; thyroid gland ; ultrasound
OBJECTIVES: The purpose of this study was to evaluate diagnostic performance of histogram analysis using grayscale ultrasound (US) images in the diagnosis of lymphocytic thyroiditis. METHODS: Three radiologists reviewed a total of 505 US images and classified the images according to the presence/existence of lymphocytic thyroiditis. After 2 months, each reviewer repeated the process with the same 505 images in a randomly mixed order. The intraobserver and interobserver variability was analyzed with a generalized κ value. Four histogram parameters (mean value, standard deviation, skewness, and kurtosis) were obtained, and an index was calculated from principal component analysis. Diagnostic performances were compared. RESULTS: Of 505 patients, 125 (24.8%) had lymphocytic thyroiditis, and 380 (75.2%) had normal thyroid parenchyma on pathologic analysis. The κ value for intraobserver variance ranged from -0.002 to 0.781, and the overall κ values for interobserver variance were 0.570 and 0.214 in the first and second tests, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for the 3 reviewers versus the principal component analysis index were 28.0% to 83.2%, 43.7% to 82.6%, 53.5% to 79.0%, 24.6% to 56.2%, and 75.2% to 88.9% versus 58.4%, 72.4%, 68.9%, 41.0%, and 84.1%. CONCLUSIONS: Histogram analysis of grayscale US images provided confirmable and quantitative information about lymphocytic thyroiditis and was comparable with performers' assessments in diagnostic performance.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김가람(Kim, Ga Ram) ORCID logo https://orcid.org/0000-0002-4481-5792
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
홍정화(Hong, Jung Hwa)
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