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Retinal vessel structure measurement using spectral-domain optical coherence tomography

Authors
 TH Rim  ;  YS Choi  ;  SS Kim  ;  M-j Kang  ;  J Oh  ;  S Park  ;  SH Byeon 
Citation
 Eye, Vol.30(1) : 111-119, 2016 
Journal Title
 Eye 
ISSN
 0950-222X 
Issue Date
2016
MeSH
Adult ; Anatomy, Cross-Sectional* ; Diagnostic Techniques, Ophthalmological* ; Humans ; Observer Variation ; Optic Disk/blood supply ; Reproducibility of Results ; Retinal Vessels/anatomy & histology* ; Retrospective Studies ; Tomography, Optical Coherence/methods*
Abstract
PURPOSE: To assess the reliability and validity of spectral-domain optical coherence tomography (SD-OCT) measurements of retinal vessel lumen diameters and wall thicknesses. METHODS: SD-OCT was used to characterize the circular region around the optic disc of 40 eyes (20 subjects). The inner and outer sides (vitreal and choroidal sides) of the vessel wall and the luminal diameter were measured using intensity graphs. RESULTS: Mean arterial and venous luminal diameters were 95.1±16.1 and 132.6±17.8 μm, respectively. The wall thicknesses of inner and outer sides of the artery were 23.9±4.9 and 21.2±3.5 μm, respectively. The wall thicknesses of the inner and outer sides of the vein were 20.7±4.2 and 16.3±4.3 μm, respectively. There were significant differences between the inner and outer wall thicknesses in both the artery and vein (P<0.01). Intra- and interobserver intraclass correlation coefficients (ICCs) for lumen measurements were >0.95, and for wall thicknesses were >0.85, except for the outer wall thickness measurements. The mean value of outer and inner wall thicknesses showed good reproducibility, with ICCs of >0.85. CONCLUSION: Intensity graph-assisted measurements using SD-OCT provided more objective information in finding boundaries of vessels. Luminal diameters and wall thicknesses obtained with OCT showed good overall reproducibility, with inner wall thicknesses being thicker, and with better reproducibility compared with outer wall thicknesses, where ICC values were the lowest among the inner wall thicknesses, mean thicknesses of inner and outer walls, and luminal diameters. When using SD-OCT measurements, caution is therefore advised when using only the outer wall as representative of the wall thicknesses.
Full Text
http://www.nature.com/eye/journal/v30/n1/full/eye2015205a.html
DOI
10.1038/eye.2015.205
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
강민재(Kang, M-j)
김성수(Kim, Sung Soo) ORCID logo https://orcid.org/0000-0002-0574-7993
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
변석호(Byeon, Suk Ho) ORCID logo https://orcid.org/0000-0001-8101-0830
오재원(Oh, Jae Won) ORCID logo https://orcid.org/0000-0002-4585-1488
임형택(Rim, Tyler Hyungtaek)
최윤성(Choi, Yoon Seong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146273
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