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위암 조직에서 Integrin α5, α6, αV, β1, β3, β4 아단위의 발현

Other Titles
 Expression of Integrin α5, α6, αV, β1, β3, β4 Subunits in Gastric Cancer 
Authors
 감창우  ;  박승우  ;  신율  ;  김현욱  ;  김한수  ;  송시영  ;  정재복  ;  강진경  ;  노성훈 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.40(6) : 355-363, 2002 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2002
Keywords
Stomach neoplasms ; Integrin ; Immunohistochemical stain
Abstract
Background/Aims: The integrins play a central role in maintaining the morphology of cell and tissue, growth, differentiation, migration, survival and apoptosis of cells, and angiogenesis. Although integrins are implicated in carcinogenesis and tumor angiogenesis, their precise contributions to the process are largely unknown. Methods: For paraffin embedded tissue samples of 102 gastric cancers (23 differentiated, 79 undifferentiated), the expression of integrin α5, α6, αV, β1, β3, β4 subunits and factor VIII were examined by immunohistochemical staining. The relationships between the expression of each integrin and several clinicopathologic parameters were analyzed. Results: The positive rates of integrins were as follows: α5 24%, β1 8%, α6 16%, β4 24%, αV 29%, and β3 34%. The expression of α5, α6, and αV was well correlated with the expression of β1, β4, and β3, respectively. The αV integrin was highly expressed in tumors of advanced T stage. The expressions of α6 and β4 integrins were significantly higher in differentiated tumors, but the β3 integrin was significantly expressed in undifferentiated tumors. The number of tumor vessels has positive correlation with αV integrin expression. Conclusions: These findings suggest that integrin α6β4 is one of the key factors in determining tumor differentiation and growth pattern. The integrin αVβ3 may be related to the angiogenesis especially in advanced gastric cancer.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kang, Jin Kyung(강진경)
Kim, Han Soo(김한수)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Shin, Yule(신율)
Chung, Jae Bock(정재복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144136
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