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Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation.

Authors
 Gitae Yoon  ;  Kyoung Ok Kim  ;  Jeonggi Lee  ;  Daeho Kwon  ;  Jeon Soo Shin  ;  Se Jong Kim  ;  In Hong Choi 
Citation
 Journal of Neuro-Oncology, Vol.60(2) : 135-141, 2002 
Journal Title
 Journal of Neuro-Oncology 
ISSN
 0167-594X 
Issue Date
2002
Abstract
Ceramide is a physiologic regulator of growth and differentiation in mammalian cells. In this study, the relationship between ceramide and FLICE inhibitory protein (FLIP) in the induction of apoptosis in glioblastoma cell lines was investigated. We found that LN215 cells were slightly more sensitive to Fas-mediated apoptosis than LN319 cells, which were more sensitive to ceramide than LN215 cells. FLIP was expressed in LN319 and LN215 cells constitutively, and this expression decreased with treatment of ceramide in LN215 cells, which might cause LN215 cells to be more sensitive to Fas-mediated apoptosis at lower level stimulation. In LN319 cells FLIP levels were not modified by ceramide treatment and the level of cell death induced by anti-Fas antibody was not affected. Our results suggest that FLIP may be down-regulated by low levels of ceramide in LN215 cells, which causes LN215 cells to be more sensitive to Fas-mediated apoptosis, whereas LN319 cells remain resistant.
Full Text
http://link.springer.com/article/10.1023/A%3A1020604705831
DOI
10.1023/A:1020604705831
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
김세종(Kim, Se Jong)
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143461
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