Cited 16 times in
Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation.
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2016-05-16T10:56:59Z | - |
dc.date.available | 2016-05-16T10:56:59Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143461 | - |
dc.description.abstract | Ceramide is a physiologic regulator of growth and differentiation in mammalian cells. In this study, the relationship between ceramide and FLICE inhibitory protein (FLIP) in the induction of apoptosis in glioblastoma cell lines was investigated. We found that LN215 cells were slightly more sensitive to Fas-mediated apoptosis than LN319 cells, which were more sensitive to ceramide than LN215 cells. FLIP was expressed in LN319 and LN215 cells constitutively, and this expression decreased with treatment of ceramide in LN215 cells, which might cause LN215 cells to be more sensitive to Fas-mediated apoptosis at lower level stimulation. In LN319 cells FLIP levels were not modified by ceramide treatment and the level of cell death induced by anti-Fas antibody was not affected. Our results suggest that FLIP may be down-regulated by low levels of ceramide in LN215 cells, which causes LN215 cells to be more sensitive to Fas-mediated apoptosis, whereas LN319 cells remain resistant. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 135~141 | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | CASP8 and FADD-LikeApoptosisRegulating Protein | - |
dc.subject.MESH | Carrier Proteins/metabolism* | - |
dc.subject.MESH | Ceramides/pharmacology* | - |
dc.subject.MESH | Down-Regulation/drug effects | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Glioblastoma* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intracellular Signaling Peptides and Proteins* | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2* | - |
dc.subject.MESH | TumorCells, Cultured/cytology | - |
dc.subject.MESH | TumorCells, Cultured/drug effects | - |
dc.subject.MESH | TumorCells, Cultured/metabolism | - |
dc.subject.MESH | bcl-2-Associated X Protein | - |
dc.subject.MESH | fas Receptor/metabolism* | - |
dc.title | Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Gitae Yoon | - |
dc.contributor.googleauthor | Kyoung Ok Kim | - |
dc.contributor.googleauthor | Jeonggi Lee | - |
dc.contributor.googleauthor | Daeho Kwon | - |
dc.contributor.googleauthor | Jeon Soo Shin | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.identifier.doi | 10.1023/A:1020604705831 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 12635660 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A%3A1020604705831 | - |
dc.subject.keyword | ceramide | - |
dc.subject.keyword | glioblastoma cell line | - |
dc.subject.keyword | Fas | - |
dc.subject.keyword | FLIP | - |
dc.subject.keyword | apoptosis | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 60 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 135 | - |
dc.citation.endPage | 141 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.60(2) : 135-141, 2002 | - |
dc.identifier.rimsid | 53182 | - |
dc.type.rims | ART | - |
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