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Clinicopathological features and prognostic significance of HER2 expression in gastric cancer

 Park J.S.  ;  Rha S.Y.  ;  Chung H.C.  ;  Jung M.  ;  Kim K.H.  ;  Jun H.J.  ;  Kim H.  ;  An J.Y.  ;  Kim H.-I.  ;  Cheong J.-H.  ;  Hyung W.J.  ;  Noh S.H.  ;  Kim H.S. 
 Oncology, Vol.88(3) : 147-156, 2015 
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BACKGROUND: HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS: A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included in this study. RESULTS: Ninety-five (11.7%) patients had HER2-positive gastric cancer. Elevated serum carcinoembryonic antigen (CEA) concentration [odds ratio (OR), 5.629; p < 0.001] and differentiated histology (OR, 3.717; p = 0.002) were significant predictive factors for HER2 positivity in localized disease. For recurrent or metastatic disease, elevated serum CEA concentration (OR, 2.545; p < 0.001), differentiated histology (OR, 3.299; p < 0.001), pulmonary metastasis (OR, 3.321; p = 0.001), and distant lymph node metastasis (OR, 2.286; p = 0.002) were significant predictive factors. Median disease-free survival (DFS) was shorter in HER2-positive patients than in others, especially in stage I or II disease (24.7 vs. 49.2 months; p < 0.001). Among HER2-negative patients with stage II diseases, patients who received adjuvant chemotherapy had longer DFS than others (42.2 vs. 30.7 months; p = 0.025). CONCLUSIONS: Clinicopathological factors may be useful in predicting the HER2 positivity of gastric cancer. Further studies are needed to understand the molecular basis of HER2-positive gastric cancer.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김기향(Kim, Ki Hyang) ; 김현기(Kim, Hyunki) ; 김형일(Kim, Hyoung Il) ; 김효송(Kim, Hyo Song) ; 노성훈(Noh, Sung Hoon) ; 라선영(Rha, Sun Young) ; 전현정(Jun, Hyun Jung) ; 정민규(Jung, Min Kyu) ; 정재호(Cheong, Jae Ho) ; 정현철(Chung, Hyun Cheol) ; 형우진(Hyung, Woo Jin)
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