Cited 16 times in
Clinicopathological features and prognostic significance of HER2 expression in gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기향 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 안지영 | - |
dc.contributor.author | 전현정 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 박지수 | - |
dc.date.accessioned | 2016-02-04T11:54:55Z | - |
dc.date.available | 2016-02-04T11:54:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141480 | - |
dc.description.abstract | BACKGROUND: HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS: A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included in this study. RESULTS: Ninety-five (11.7%) patients had HER2-positive gastric cancer. Elevated serum carcinoembryonic antigen (CEA) concentration [odds ratio (OR), 5.629; p < 0.001] and differentiated histology (OR, 3.717; p = 0.002) were significant predictive factors for HER2 positivity in localized disease. For recurrent or metastatic disease, elevated serum CEA concentration (OR, 2.545; p < 0.001), differentiated histology (OR, 3.299; p < 0.001), pulmonary metastasis (OR, 3.321; p = 0.001), and distant lymph node metastasis (OR, 2.286; p = 0.002) were significant predictive factors. Median disease-free survival (DFS) was shorter in HER2-positive patients than in others, especially in stage I or II disease (24.7 vs. 49.2 months; p < 0.001). Among HER2-negative patients with stage II diseases, patients who received adjuvant chemotherapy had longer DFS than others (42.2 vs. 30.7 months; p = 0.025). CONCLUSIONS: Clinicopathological factors may be useful in predicting the HER2 positivity of gastric cancer. Further studies are needed to understand the molecular basis of HER2-positive gastric cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoembryonic Antigen/blood | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis/genetics | - |
dc.subject.MESH | Lymphatic Metastasis/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/genetics | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Receptor, ErbB-2/genetics* | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism* | - |
dc.subject.MESH | Stomach Neoplasms/genetics | - |
dc.subject.MESH | Stomach Neoplasms/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinicopathological features and prognostic significance of HER2 expression in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Park J.S. | - |
dc.contributor.googleauthor | Rha S.Y. | - |
dc.contributor.googleauthor | Chung H.C. | - |
dc.contributor.googleauthor | Jung M. | - |
dc.contributor.googleauthor | Kim K.H. | - |
dc.contributor.googleauthor | Jun H.J. | - |
dc.contributor.googleauthor | Kim H. | - |
dc.contributor.googleauthor | An J.Y. | - |
dc.contributor.googleauthor | Kim H.-I. | - |
dc.contributor.googleauthor | Cheong J.-H. | - |
dc.contributor.googleauthor | Hyung W.J. | - |
dc.contributor.googleauthor | Noh S.H. | - |
dc.contributor.googleauthor | Kim H.S. | - |
dc.identifier.doi | 10.1159/000368555 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00342 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A03561 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02416 | - |
dc.identifier.eissn | 1423-0232 | - |
dc.identifier.pmid | 25402270 | - |
dc.identifier.url | http://www.karger.com/?DOI=10.1159/000368555 | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | HER2 | - |
dc.subject.keyword | Predictive factor | - |
dc.subject.keyword | Chemotherapy | - |
dc.contributor.alternativeName | Kim, Ki Hyang | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | An, Ji Yeong | - |
dc.contributor.alternativeName | Jun, Hyun Jung | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ki Hyang | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Jun, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 88 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 156 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, Vol.88(3) : 147-156, 2015 | - |
dc.identifier.rimsid | 30671 | - |
dc.type.rims | ART | - |
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