0 241

Cited 0 times in

Accelerated Bone Formation in Distracted Alveolar Bone After Injection of Recombinant Human Bone Morphogenetic Protein-2

Authors
 Munkhdulam Terbish  ;  Seong Hun Yoo  ;  Hee Jin Kim  ;  Hyung Seog Yu  ;  Chung Ju Hwang  ;  Hyung Seon Baik  ;  Jung Yul Cha 
Citation
 Journal of Periodontology, Vol.86(9) : 1078-1086, 2015 
Journal Title
 Journal of Periodontology 
ISSN
 0022-3492 
Issue Date
2015
Abstract
BACKGROUND: This study evaluates the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the quality and quantity of regenerated bone when injected into distracted alveolar bone. METHODS: Sixteen adult beagle dogs were assigned to either the control or rhBMP-2 group. After distraction was completed, an rhBMP-2 dose of 330 μg in 0.33 mL was injected slowly into the distracted alveolar crest of the mesial, middle, and distal parts of the alveolar bone in the experimental group. Histologic and microcomputed tomography analyses of regenerated bone were done after 2 and 6 weeks of consolidation. RESULTS: After 6 weeks of consolidation, the vertical defect height in the middle of the regenerated bone was significantly lower in the rhBMP-2 group (2.2 mm) than in the control group (3.4 mm) (P <0.05). Additionally, the width of the regenerated bone was significantly greater in the rhBMP-2 group (4.3 mm) than in the control group (2.8 mm) (P <0.05). The bone density and volume of regenerated bone in the rhBMP-2 group were greater than in the control group after 6 weeks of consolidation (P <0.001). CONCLUSION: Injection of rhBMP-2 into regenerated bone after a distraction osteogenesis procedure significantly increased bone volume in the dentoalveolar distraction site and improved both the width and height of the alveolar ridge and increased the bone density.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141467
DOI
10.1902/jop.2015.140697
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Craniofacial Deformity (두개안면기형연구소)
Yonsei Authors
김희진(Kim, Hee Jin) ; 뭉해돌람(Terbish, Munkhdulam) ; 백형선(Baik, Hyoung Seon) ; 유형석(Yu, Hyung Seog) ; 차정열(Cha, Jung Yul) ; 황충주(Hwang, Chung Ju)
사서에게 알리기
  feedback
Full Text
http://www.joponline.org/doi/abs/10.1902/jop.2015.140697
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse