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Accelerated Bone Formation in Distracted Alveolar Bone After Injection of Recombinant Human Bone Morphogenetic Protein-2

 Munkhdulam Terbish  ;  Seong Hun Yoo  ;  Hee Jin Kim  ;  Hyung Seog Yu  ;  Chung Ju Hwang  ;  Hyung Seon Baik  ;  Jung Yul Cha 
 JOURNAL OF PERIODONTOLOGY, Vol.86(9) : 1078-1086, 2015 
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Issue Date
Bone morphogenetic protein 2 ; bone regeneration ; bonetissue ; drug delivery systems ; osteogenesis, distraction
BACKGROUND: This study evaluates the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the quality and quantity of regenerated bone when injected into distracted alveolar bone. METHODS: Sixteen adult beagle dogs were assigned to either the control or rhBMP-2 group. After distraction was completed, an rhBMP-2 dose of 330 μg in 0.33 mL was injected slowly into the distracted alveolar crest of the mesial, middle, and distal parts of the alveolar bone in the experimental group. Histologic and microcomputed tomography analyses of regenerated bone were done after 2 and 6 weeks of consolidation. RESULTS: After 6 weeks of consolidation, the vertical defect height in the middle of the regenerated bone was significantly lower in the rhBMP-2 group (2.2 mm) than in the control group (3.4 mm) (P <0.05). Additionally, the width of the regenerated bone was significantly greater in the rhBMP-2 group (4.3 mm) than in the control group (2.8 mm) (P <0.05). The bone density and volume of regenerated bone in the rhBMP-2 group were greater than in the control group after 6 weeks of consolidation (P <0.001). CONCLUSION: Injection of rhBMP-2 into regenerated bone after a distraction osteogenesis procedure significantly increased bone volume in the dentoalveolar distraction site and improved both the width and height of the alveolar ridge and increased the bone density.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Craniofacial Deformity (두개안면기형연구소) > 1. Journal Papers
Yonsei Authors
Kim, Hee Jin(김희진) ORCID logo https://orcid.org/0000-0002-1139-6261
Terbish, Munkhdulam(뭉해돌람)
Baik, Hyoung Seon(백형선)
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Cha, Jung Yul(차정열)
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
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