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Botulinum toxin A affects early capsule formation around silicone implants in a rat model

 Kim, Young Seok  ;  Hong, Jong Won  ;  Yoon, Jung Ho  ;  Hwang, Yong Seok  ;  Roh, Tai Suk  ;  Rah, Dong Kyun 
 ANNALS OF PLASTIC SURGERY, Vol.74(4) : 488-495, 2015 
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Issue Date
Animals ; Botulinum Toxins, Type A/therapeutic use* ; Implant Capsular Contracture/prevention & control* ; Male ; Neuromuscular Agents/therapeutic use* ; Prostheses and Implants* ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Silicone Gels* ; Treatment Outcome
botulinum toxin A ; capsule ; contracture ; implant
Capsular contracture is one of the most common complications resulting from implants placed during mammoplasty and rhinoplasty, and there is no definitive solution or a method for preventing it. Recent reports suggest that botulinum toxin A (BoTA) is effective at reducing keloid scars clinically. Peri-implant capsules are histologically similar to keloid scars and hypertrophic scars. Therefore, we hypothesized that BoTA may reduce peri-implant capsule formation.To test our hypothesis, we divided 24 male Sprague-Dawley rats into an experiment group and a control group. We created two 15 × 15-mm subpanniculus pockets in each rat. Botulinum toxin A (0.5 mL; 5 U) was injected into the carnosa layer of the experimental group's pockets and 0.5 mL normal saline was similarly injected in the control group. Hemispherical silicone implants, 15 mm in diameter, were inserted into the pockets. After 6 weeks, the peri-implant capsule was excised and examined by histologic evaluation, immunohistochemical stain, scanning electron microscope, and real-time polymerase chain reaction.Capsular thickness, number of inflammatory cells, number of vessels, and transforming growth factor β1 expression were reduced in the experimental group compared to the control group (P < 0.01). The experimental group's collagen pattern was loose and well organized. The total myofibroblast content was lower in the experimental group than in the control group; however, this difference was not statistically significant (P = 0.32). Additionally, the experimental group had a smaller fibrosis index than the control group (P < 0.05).Our results suggest that BoTA may provide an alternative treatment for reducing capsule formation and preventing contracture, and further studies may reveal the mechanism of action.
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1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Seok(김영석) ORCID logo https://orcid.org/0000-0002-0981-2107
Rah, Dong Kyun(나동균)
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Yoon, Jung Ho(윤정호)
Hong, Jong Won(홍종원) ORCID logo https://orcid.org/0000-0002-7762-0940
Hwang, Yong Seok(황용석)
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