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Prognostic value of SYNTAX score based on coronary computed tomography angiography

Authors
 Young Joo Suh  ;  Yoo Jin Hong  ;  Hye-Jeong Lee  ;  Jin Hur  ;  Young Jin Kim  ;  Hye Sun Lee  ;  Sae Rom Hong  ;  Dong Jin Im  ;  Yun Jung Kim  ;  Chul Hwan Park  ;  Tae Hoon Kim  ;  Kyung-Jong Yoo  ;  Byoung Wook Choi 
Citation
 International Journal of Cardiology, Vol.199 : 460-466, 2015 
Journal Title
 International Journal of Cardiology 
ISSN
 0167-5273 
Issue Date
2015
Abstract
BACKGROUND: The long-term prognostic value of the computed tomography (CT)-based SYNTAX score has not yet been investigated. The aim of our study was to investigate the prognostic value of the CT-SYNTAX score in predicting major adverse cardiac events (MACEs) in populations who underwent both coronary computed tomography (CCTA) and invasive coronary angiography (ICA), compared with prognostic values of coronary artery disease (CAD) findings on CCTA and the ICA-based SYNTAX score. METHODS: We retrospectively included 339 patients (213 men, mean age of 63.8±9.45years) with suspected CAD who underwent CCTA and ICA. SYNTAX score was obtained based on both CCTA and ICA. Follow-up clinical outcome data regarding composite MACEs were obtained. Cox proportional hazard models were developed to predict MACEs based on clinical variables, number of CAD vessels, and SYNTAX scores based on CCTA and ICA. The time-dependent receiver operating characteristic curve method was used, and the integrated area under the curve (iAUC) was calculated to compare the predictive prognosis of the models. RESULTS: During the median follow-up of 1374days, there were 30 MACEs. In multivariate Cox regression adjusted for clinical variables, SYNTAX score group 4 (≥33) on CCTA and SYNTAX score groups 3 (23-32) and 4 (≥33) on ICA showed increased hazard ratios for MACEs compared to SYNTAX score group 1 (0). CT-SYNTAX score demonstrated no significant difference in iAUC compared with ICA-SYNTAX score and the number of vessels of CAD on CCTA. CONCLUSIONS: CT-SYNTAX score can be a useful method for non-invasively predicting MACEs, especially in patients with complex CAD.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141294
DOI
10.1016/j.ijcard.2015.07.067
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김영진(Kim, Young Jin) ; 김윤정(Kim, Yun Jung) ; 김태훈(Kim, Tae Hoon) ; 박철환(Park, Chul Hwan) ; 서영주(Suh, Young Joo) ; 유경종(Yoo, Kyung Jong) ; 이혜선(Lee, Hye Sun) ; 이혜정(Lee, Hye Jeong) ; 임동진(Im, Dong Jin) ; 최병욱(Choi, Byoung Wook) ; 허진(Hur, Jin) ; 홍새롬(Hong, Sae Rom) ; 홍유진(Hong, Yoo Jin)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0167527315301881
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