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Prognostic value of SYNTAX score based on coronary computed tomography angiography

Authors
 Young Joo Suh  ;  Yoo Jin Hong  ;  Hye-Jeong Lee  ;  Jin Hur  ;  Young Jin Kim  ;  Hye Sun Lee  ;  Sae Rom Hong  ;  Dong Jin Im  ;  Yun Jung Kim  ;  Chul Hwan Park  ;  Tae Hoon Kim  ;  Kyung-Jong Yoo  ;  Byoung Wook Choi 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.199 : 460-466, 2015 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2015
MeSH
Adrenergic beta-1 Receptor Antagonists/administration & dosage ; Aged ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging* ; Coronary Artery Disease/drug therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Metoprolol/administration & dosage ; Middle Aged ; Nitroglycerin/administration & dosage ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed/methods* ; Vasodilator Agents/administration & dosage
Keywords
Coronary computed tomography angiography ; Prognosis ; SYNTAX score
Abstract
BACKGROUND: The long-term prognostic value of the computed tomography (CT)-based SYNTAX score has not yet been investigated. The aim of our study was to investigate the prognostic value of the CT-SYNTAX score in predicting major adverse cardiac events (MACEs) in populations who underwent both coronary computed tomography (CCTA) and invasive coronary angiography (ICA), compared with prognostic values of coronary artery disease (CAD) findings on CCTA and the ICA-based SYNTAX score. METHODS: We retrospectively included 339 patients (213 men, mean age of 63.8±9.45years) with suspected CAD who underwent CCTA and ICA. SYNTAX score was obtained based on both CCTA and ICA. Follow-up clinical outcome data regarding composite MACEs were obtained. Cox proportional hazard models were developed to predict MACEs based on clinical variables, number of CAD vessels, and SYNTAX scores based on CCTA and ICA. The time-dependent receiver operating characteristic curve method was used, and the integrated area under the curve (iAUC) was calculated to compare the predictive prognosis of the models. RESULTS: During the median follow-up of 1374days, there were 30 MACEs. In multivariate Cox regression adjusted for clinical variables, SYNTAX score group 4 (≥33) on CCTA and SYNTAX score groups 3 (23-32) and 4 (≥33) on ICA showed increased hazard ratios for MACEs compared to SYNTAX score group 1 (0). CT-SYNTAX score demonstrated no significant difference in iAUC compared with ICA-SYNTAX score and the number of vessels of CAD on CCTA. CONCLUSIONS: CT-SYNTAX score can be a useful method for non-invasively predicting MACEs, especially in patients with complex CAD.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527315301881
DOI
10.1016/j.ijcard.2015.07.067
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Yun Jung(김윤정)
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Im, Dong Jin(임동진) ORCID logo https://orcid.org/0000-0001-8139-5646
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Sae Rom(홍새롬)
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141294
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