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The influence of body mass index on the diagnostic performance of pre-operative staging ultrasound in papillary thyroid carcinoma

 Ji Soo Choi  ;  Hye Sun Lee  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jin Young Kwak 
 CLINICAL ENDOCRINOLOGY, Vol.83(4) : 550-555, 2015 
Journal Title
Issue Date
Adult ; Body Mass Index* ; Carcinoma/diagnosis* ; Carcinoma/diagnostic imaging* ; Carcinoma/surgery ; Carcinoma, Papillary ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/surgery ; Ultrasonography
OBJECTIVE: The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging US and surgical excision at a referral centre between December 2012 and April 2013. Four experienced radiologists prospectively evaluated the extent of primary tumours, multifocality and the presence of lymph node metastasis. Patients were grouped according to BMI (normal <25; overweight 25 ≤ and <30; obese ≥30, or nonobese <30; obese ≥30 kg/m(2) ). Diagnostic performances of pre-operative staging US (sensitivity, specificity, positive predictive value, negative predictive value and accuracy) were compared according to BMI based on pathologic findings of surgical specimens. RESULTS: Pre-operative staging US in the obese group (BMI ≥30 kg/m(2) ) showed a significantly lower negative predictive value and accuracy in the detection of central lymph node metastasis (P = 0·010 and P = 0·025, respectively) than in the nonobese (BMI <30 kg/m(2) ) group. However, there were no significant differences in the diagnostic performance of pre-operative staging US for extrathyroidal extension, bilateral multifocality and lateral lymph node metastasis in analyses using the two (nonobese vs obese) and three BMI (normal vs overweight vs obese) groups, respectively. CONCLUSION: Obesity (BMI ≥30 kg/m(2) ) may affect the pre-operative US staging of central lymph node metastasis in patients with PTC.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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