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Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients

Authors
 Yunseon Choi  ;  Ik Jae Lee  ;  Chang Young Lee  ;  Jae Ho Cho  ;  Won Hoon Choi  ;  Hong In Yoon  ;  Yun-Han Lee  ;  Chang Geol Lee  ;  Ki Chang Keum  ;  Kyung Young Chung  ;  Seok Jin Haam  ;  Hyo Chae Paik  ;  Kang Kyoo Lee  ;  Sun Rock Moon  ;  Jong-Young Lee  ;  Kyung-Ran Park  ;  Young Suk Kim 
Citation
 Radiation Oncology Journal, Vol.33(2) : 75-82, 2015 
Journal Title
 Radiation Oncology Journal 
ISSN
 2234-1900 
Issue Date
2015
Abstract
PURPOSE: We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of invasion: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor <2 cm distal to the carina, and tumor-associated collapse. RESULTS: The median overall survival (OS) and disease-free survival (DFS) were 55.3 months and 51.2 months, respectively. In postoperative T3N0M0 patients, the tumor size was a significant prognostic factor for survival (OS, p = 0.035 and DFS, p = 0.035, respectively). Patients with endobronchial tumors within 2 cm of the carina also showed better OS and DFS than those in the other T3 subtypes (p = 0.018 and p = 0.016, respectively). However, adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Only patients with mediastinal pleural invasion (n = 25) demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively). CONCLUSION: The T3N0 NSCLC subtype that showed the most favorable prognosis is the one with endobronchial tumors within 2 cm of the carina. Adjuvant radiotherapy is not effective in improving survival outcome in resected T3N0 NSCLC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140668
DOI
10.3857/roj.2015.33.2.75
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
금기창(Keum, Ki Chang) ; 백효채(Paik, Hyo Chae) ; 윤홍인(Yoon, Hong In) ; 이윤한(Lee, Yun Han) ; 이익재(Lee, Ik Jae) ; 이창걸(Lee, Chang Geol) ; 이창영(Lee, Chang Young) ; 정경영(Chung, Kyung Young) ; 조재호(Cho, Jae Ho) ; 최원훈(Choi, Won Hoon) ; 함석진(Haam, Seok Jin)
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