Cited 8 times in
Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients
DC Field | Value | Language |
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dc.contributor.author | 이익재 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 최원훈 | - |
dc.contributor.author | 함석진 | - |
dc.contributor.author | 금기창 | - |
dc.contributor.author | 백효채 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 이윤한 | - |
dc.date.accessioned | 2016-02-04T11:32:49Z | - |
dc.date.available | 2016-02-04T11:32:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2234-1900 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140668 | - |
dc.description.abstract | PURPOSE: We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of invasion: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor <2 cm distal to the carina, and tumor-associated collapse. RESULTS: The median overall survival (OS) and disease-free survival (DFS) were 55.3 months and 51.2 months, respectively. In postoperative T3N0M0 patients, the tumor size was a significant prognostic factor for survival (OS, p = 0.035 and DFS, p = 0.035, respectively). Patients with endobronchial tumors within 2 cm of the carina also showed better OS and DFS than those in the other T3 subtypes (p = 0.018 and p = 0.016, respectively). However, adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Only patients with mediastinal pleural invasion (n = 25) demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively). CONCLUSION: The T3N0 NSCLC subtype that showed the most favorable prognosis is the one with endobronchial tumors within 2 cm of the carina. Adjuvant radiotherapy is not effective in improving survival outcome in resected T3N0 NSCLC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 75~82 | - |
dc.relation.isPartOf | RADIATION ONCOLOGY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Yunseon Choi | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Jae Ho Cho | - |
dc.contributor.googleauthor | Won Hoon Choi | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Yun-Han Lee | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Seok Jin Haam | - |
dc.contributor.googleauthor | Hyo Chae Paik | - |
dc.contributor.googleauthor | Kang Kyoo Lee | - |
dc.contributor.googleauthor | Sun Rock Moon | - |
dc.contributor.googleauthor | Jong-Young Lee | - |
dc.contributor.googleauthor | Kyung-Ran Park | - |
dc.contributor.googleauthor | Young Suk Kim | - |
dc.identifier.doi | 10.3857/roj.2015.33.2.75 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03571 | - |
dc.contributor.localId | A04129 | - |
dc.contributor.localId | A04335 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A01846 | - |
dc.contributor.localId | A03029 | - |
dc.contributor.localId | A04777 | - |
dc.relation.journalcode | J02592 | - |
dc.identifier.eissn | 2234-3164 | - |
dc.identifier.pmid | 26157676 | - |
dc.subject.keyword | Adjuvant radiotherapy | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | Prognostic factor | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Choi, Won Hoon | - |
dc.contributor.alternativeName | Haam, Seok Jin | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Paik, Hyo Chae | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.alternativeName | Lee, Yun Han | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Choi, Won Hoon | - |
dc.contributor.affiliatedAuthor | Haam, Seok Jin | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Paik, Hyo Chae | - |
dc.contributor.affiliatedAuthor | Lee, Yun Han | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 82 | - |
dc.identifier.bibliographicCitation | RADIATION ONCOLOGY JOURNAL, Vol.33(2) : 75-82, 2015 | - |
dc.identifier.rimsid | 30236 | - |
dc.type.rims | ART | - |
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