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Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer

 Mina Park  ;  Yong Eun Chung  ;  Kyung Ah Kim  ;  Woo-Suk Chung  ;  Hye Sun Lee  ;  Kyung Hwa Han  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
 PLOS ONE, Vol.10(2) : e0114819, 2015 
Journal Title
Issue Date
Aged ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/pathology* ; Female ; Humans ; Image Enhancement/methods* ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Tomography, X-Ray Computed/methods*
OBJECTIVE: To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions.

SUBJECTS AND METHODS: We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller than 3 cm (123 total lesions; metastasis: benign = 32:91). AEF color maps of the liver were created from multiphasic liver CT images using dedicated software. Two radiologists independently reviewed multiphasic CT image sets alone and in combination with image sets with AEF color maps using a five-point scale. The additional diagnostic value of the color maps was assessed by means of receiver-operating characteristic (ROC) analysis.

RESULTS: The area under the ROC curve (Az) increased when multiphasic CT images were combined with AEF color map analysis as compared with evaluation based only on multiphasic CT images (from 0.698 to 0.897 for reader 1, and from 0.825 to 0.945 for reader 2; P < 0.001 and 0.002, respectively). The increase Az was especially significant for lesions less than 1 cm (from 0.702 to 0.888 for reader 1, and from 0.768 to 0.958 for reader 2; P = 0.001 and P = 0.001, respectively). The mean AEF of tumor-adjacent parenchyma (35.07 ± 27.2) was significantly higher than that of tumor-free liver parenchyma (27.3 ± 20.6) (P = 0.04).

CONCLUSIONS: AEF color mapping can improve the diagnostic performance for small hepatic metastases from colorectal cancer and may allow for the elimination of additional examinations.
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1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Han, Kyung Hwa(한경화)
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