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Normal range of hepatic fat fraction on dual- and triple-echo fat quantification MR in children

 Hyun Joo Shin  ;  Hyun Gi Kim  ;  Myung-Joon Kim  ;  Hong Koh  ;  Ha Yan Kim  ;  Yun Ho Roh  ;  Mi-Jung Lee 
 PLOS ONE, Vol.10(2) : e0117480, 2015 
Journal Title
Issue Date
Adipose Tissue/diagnostic imaging* ; Adolescent ; Child ; Child, Preschool ; Echo-Planar Imaging* ; Fatty Liver/diagnostic imaging* ; Female ; Humans ; Liver/diagnostic imaging* ; Male ; Radiography ; Retrospective Studies
OBJECTIVES: To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS: We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal laboratory findings or those who were overweight. Hepatic fat fraction was measured on dual- and triple-echo sequences using 3T MRI. We compared fat fractions using the Wilcoxon signed rank test and the Bland-Altman 95% limits of agreement. The correlation between fat fractions and clinical and laboratory findings was evaluated using Spearman's correlation test, and the cut-off values of fat fractions for diagnosing fatty liver were obtained from reference intervals. RESULTS: In 54 children (M:F = 26:28; 5-15 years; mean 9 years), the dual fat fraction (0.1-8.0%; median 1.6%) was not different from the triple fat fraction (0.4-6.5%; median 2.7%) (p = 0.010). The dual- and triple-echo fat fractions showed good agreement using a Bland-Altman plot (-0.6 ± 2.8%). Eight children (14.8%) on dual-echo sequences and six (11.1%) on triple-echo sequences had greater than 5% fat fraction. From these children, six out of eight children on dual-echo sequences and four out of six children on triple-echo sequences had a 5-6% hepatic fat fraction. When using a cut-off value of a 6% fat fraction derived from a reference interval, only 3.7% of children were diagnosed with fatty liver. There was no significant correlation between clinical and laboratory findings with dual and triple-echo fat fractions. CONCLUSIONS: Dual fat fraction was not different from triple fat fraction. We suggest a cut-off value of a 6% fat fraction is more appropriate for diagnosing fatty liver on both dual- and triple-echo sequences in children.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Kim, Ha Yan(김하얀)
Kim, Hyun Gi(김현지)
Roh, Yun Ho(노윤호)
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
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