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Normal range of hepatic fat fraction on dual- and triple-echo fat quantification MR in children

Authors
 Hyun Joo Shin  ;  Hyun Gi Kim  ;  Myung-Joon Kim  ;  Hong Koh  ;  Ha Yan Kim  ;  Yun Ho Roh  ;  Mi-Jung Lee 
Citation
 PLoS One, Vol.10(2) : e0117480, 2015 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2015
Abstract
OBJECTIVES: To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS: We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal laboratory findings or those who were overweight. Hepatic fat fraction was measured on dual- and triple-echo sequences using 3T MRI. We compared fat fractions using the Wilcoxon signed rank test and the Bland-Altman 95% limits of agreement. The correlation between fat fractions and clinical and laboratory findings was evaluated using Spearman's correlation test, and the cut-off values of fat fractions for diagnosing fatty liver were obtained from reference intervals. RESULTS: In 54 children (M:F = 26:28; 5-15 years; mean 9 years), the dual fat fraction (0.1-8.0%; median 1.6%) was not different from the triple fat fraction (0.4-6.5%; median 2.7%) (p = 0.010). The dual- and triple-echo fat fractions showed good agreement using a Bland-Altman plot (-0.6 ± 2.8%). Eight children (14.8%) on dual-echo sequences and six (11.1%) on triple-echo sequences had greater than 5% fat fraction. From these children, six out of eight children on dual-echo sequences and four out of six children on triple-echo sequences had a 5-6% hepatic fat fraction. When using a cut-off value of a 6% fat fraction derived from a reference interval, only 3.7% of children were diagnosed with fatty liver. There was no significant correlation between clinical and laboratory findings with dual and triple-echo fat fractions. CONCLUSIONS: Dual fat fraction was not different from triple fat fraction. We suggest a cut-off value of a 6% fat fraction is more appropriate for diagnosing fatty liver on both dual- and triple-echo sequences in children.
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DOI
10.1371/journal.pone.0117480
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
고홍(Koh, Hong) ORCID logo https://orcid.org/0000-0002-3660-7483
김명준(Kim, Myung Joon) ORCID logo https://orcid.org/0000-0002-4608-0275
김하얀(Kim, Ha Yan)
김현지(Kim, Hyun Gi)
노윤호(Roh, Yun Ho)
신현주(Shin, Hyun Joo) ORCID logo https://orcid.org/0000-0002-7462-2609
이미정(Lee, Mi-Jung) ORCID logo https://orcid.org/0000-0003-3244-9171
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139410
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