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Standardized uptake value of ¹⁸F-fluorodeoxyglucose positron emission tomography for prediction of tumor recurrence in breast cancer beyond tumor burden.

Authors
 Sung Gwe Ahn  ;  Jong Tae Park  ;  Hak Min Lee  ;  Hak Woo Lee  ;  Tae Joo Jeon  ;  Kyunghwa Han  ;  Seung Ah Lee  ;  Seung Myung Dong  ;  Young Hoon Ryu  ;  Eun Ju Son  ;  Joon Jeong 
Citation
 BREAST CANCER RESEARCH, Vol.16(502) : 1-10, 2014 
Journal Title
 BREAST CANCER RESEARCH 
ISSN
 1465-5411 
Issue Date
2014
MeSH
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology ; Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Carcinoma, Ductal, Breast/diagnostic imaging* ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Lobular/diagnostic imaging* ; Carcinoma, Lobular/pathology ; Cohort Studies ; Decision Support Techniques ; Female ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging* ; Neoplasm Recurrence, Local/pathology ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies ; Tumor Burden*
Keywords
Breast Cancer ; Maximum Standardize Uptake ; High SUVmax ; Luminal Breast Cancer ; Gangnam Severance Hospital
Abstract
INTRODUCTION: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can reveal the metabolic activity of malignant tumors. Recent advances gained from molecular studies suggest that tumor biology can be a good predictor of prognosis in breast cancer. We compared the ability of maximum standardized uptake values (SUVmax) derived by FDG-PET with tumor burden in predicting tumor recurrence for patients with breast cancer. METHODS: 496 patients with breast cancer who underwent preoperative FDG-PET between April 2004 and May 2009 were retrospectively identified. SUVmax was obtained by FDG-PET, and the cutoff point was defined using a time-dependent receiver operating characteristic curve for recurrence-free survival (RFS). The primary endpoint was RFS. RESULTS: In multivariate analysis for RFS, SUVmax carried independent prognostic significance (hazard ratio, 2.39; 95% confidence interval, 1.20 to 4.76; P = 0.012). When the patients were classified into four groups according to the combined factors of tumor size (≤2 cm versus >2 cm) and SUVmax (<4 versus ≥4), RFS differed significantly (P < 0.001). Similarly, SUVmax had prognostic value in combination with nodal status (negative versus positive) or stage (I versus II and III) (P < 0.001 and P = 0.001, respectively). In hormone receptor-positive disease, SUVmax remained a significant prognostic factor for RFS based on multivariate analysis. CONCLUSIONS: Our results highlight the prognostic value of FDG-PET in prediction of tumor relapse for patients with breast cancer. Particularly in patients with hormone receptor-positive disease, the tumor metabolic information provided by FDG-PET is more significantly correlated with prognosis than tumor burden.
Files in This Item:
T201405462.pdf Download
DOI
10.1186/s13058-014-0502-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Tae(박종태)
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Hak Min(이학민)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138680
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