Cited 8 times in
Standardized uptake value of ¹⁸F-fluorodeoxyglucose positron emission tomography for prediction of tumor recurrence in breast cancer beyond tumor burden.
DC Field | Value | Language |
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dc.contributor.author | 박종태 | - |
dc.contributor.author | 손은주 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이학민 | - |
dc.contributor.author | 전태주 | - |
dc.contributor.author | 정준 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2015-12-28T11:05:41Z | - |
dc.date.available | 2015-12-28T11:05:41Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1465-5411 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138680 | - |
dc.description.abstract | INTRODUCTION: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can reveal the metabolic activity of malignant tumors. Recent advances gained from molecular studies suggest that tumor biology can be a good predictor of prognosis in breast cancer. We compared the ability of maximum standardized uptake values (SUVmax) derived by FDG-PET with tumor burden in predicting tumor recurrence for patients with breast cancer. METHODS: 496 patients with breast cancer who underwent preoperative FDG-PET between April 2004 and May 2009 were retrospectively identified. SUVmax was obtained by FDG-PET, and the cutoff point was defined using a time-dependent receiver operating characteristic curve for recurrence-free survival (RFS). The primary endpoint was RFS. RESULTS: In multivariate analysis for RFS, SUVmax carried independent prognostic significance (hazard ratio, 2.39; 95% confidence interval, 1.20 to 4.76; P = 0.012). When the patients were classified into four groups according to the combined factors of tumor size (≤2 cm versus >2 cm) and SUVmax (<4 versus ≥4), RFS differed significantly (P < 0.001). Similarly, SUVmax had prognostic value in combination with nodal status (negative versus positive) or stage (I versus II and III) (P < 0.001 and P = 0.001, respectively). In hormone receptor-positive disease, SUVmax remained a significant prognostic factor for RFS based on multivariate analysis. CONCLUSIONS: Our results highlight the prognostic value of FDG-PET in prediction of tumor relapse for patients with breast cancer. Particularly in patients with hormone receptor-positive disease, the tumor metabolic information provided by FDG-PET is more significantly correlated with prognosis than tumor burden. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~10 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Breast Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma/diagnostic imaging | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/pathology | - |
dc.subject.MESH | Carcinoma, Lobular/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Lobular/pathology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Decision Support Techniques | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnostic imaging* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiopharmaceuticals | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tumor Burden* | - |
dc.title | Standardized uptake value of ¹⁸F-fluorodeoxyglucose positron emission tomography for prediction of tumor recurrence in breast cancer beyond tumor burden. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Jong Tae Park | - |
dc.contributor.googleauthor | Hak Min Lee | - |
dc.contributor.googleauthor | Hak Woo Lee | - |
dc.contributor.googleauthor | Tae Joo Jeon | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Seung Ah Lee | - |
dc.contributor.googleauthor | Seung Myung Dong | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Eun Ju Son | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1186/s13058-014-0502-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01988 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03272 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A04267 | - |
dc.contributor.localId | A03557 | - |
dc.contributor.localId | A01663 | - |
dc.relation.journalcode | J00402 | - |
dc.identifier.eissn | 1465-542X | - |
dc.identifier.pmid | 25551703 | - |
dc.subject.keyword | Breast Cancer | - |
dc.subject.keyword | Maximum Standardize Uptake | - |
dc.subject.keyword | High SUVmax | - |
dc.subject.keyword | Luminal Breast Cancer | - |
dc.subject.keyword | Gangnam Severance Hospital | - |
dc.contributor.alternativeName | Park, Jong Tae | - |
dc.contributor.alternativeName | Son, Eun Ju | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Hak Min | - |
dc.contributor.alternativeName | Jeon, Tae Joo | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Son, Eun Ju | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Hak Min | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Park, Jong Tae | - |
dc.citation.volume | 16 | - |
dc.citation.number | 502 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH, Vol.16(502) : 1-10, 2014 | - |
dc.identifier.rimsid | 57340 | - |
dc.type.rims | ART | - |
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