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Peptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide

 Inho Park  ;  In Hong Choi  ;  Jeon Soo Shin  ;  Se Jong Kim 
 Yonsei Medical Journal, Vol.45(4) : 755-758, 2004 
Journal Title
 Yonsei Medical Journal 
Issue Date
The antigenic similarity between Neisseria meningitidis group B (NMGB) capsular polysaccharide (PS) and human polysialic acid (PSA) has hampered the development of a NMGB PS-based vaccine. But the possibility of a safe vaccine based on NMGB PS has been demonstrated by the existence of the NMGB PS-associated nonautoreactive epitope, which is distinct from those present on human PSA. To obtain peptide mimotopes of NMGB PS, we used HmenB3, a protective and nonautoreactive monoclonal antibody, to screen a phage library with 12 amino acids. We obtained 23 phage clones that bound to HmenB3 but not in the presence of E. coli K1 PS [which is α(2-8) -linked PSA like NMGB PS]. The clones contained 3 mimotopes and differed from previously described NMGB PS mimotopes. Immunization with a synthetic peptide of one mimotope elicited anti-NMGB antibodies in BALB/c mice. These mimotopes may be useful in the development of group B meningococcal vaccines.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
김세종(Kim, Se Jong)
박인호(Park, Inho) ORCID logo https://orcid.org/0000-0003-2190-5469
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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