Cited 18 times in
Peptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 박인호 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-07-14T17:15:27Z | - |
dc.date.available | 2015-07-14T17:15:27Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112521 | - |
dc.description.abstract | The antigenic similarity between Neisseria meningitidis group B (NMGB) capsular polysaccharide (PS) and human polysialic acid (PSA) has hampered the development of a NMGB PS-based vaccine. But the possibility of a safe vaccine based on NMGB PS has been demonstrated by the existence of the NMGB PS-associated nonautoreactive epitope, which is distinct from those present on human PSA. To obtain peptide mimotopes of NMGB PS, we used HmenB3, a protective and nonautoreactive monoclonal antibody, to screen a phage library with 12 amino acids. We obtained 23 phage clones that bound to HmenB3 but not in the presence of E. coli K1 PS [which is α(2-8) -linked PSA like NMGB PS]. The clones contained 3 mimotopes and differed from previously described NMGB PS mimotopes. Immunization with a synthetic peptide of one mimotope elicited anti-NMGB antibodies in BALB/c mice. These mimotopes may be useful in the development of group B meningococcal vaccines. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 755~758 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Vaccines/immunology* | - |
dc.subject.MESH | Cloning, Molecular | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Meningococcal Infections/immunology* | - |
dc.subject.MESH | Meningococcal Infections/prevention & control* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Neisseria meningitidis, Serogroup B/genetics | - |
dc.subject.MESH | Neisseria meningitidis, Serogroup B/immunology* | - |
dc.subject.MESH | Polysaccharides, Bacterial/genetics | - |
dc.subject.MESH | Polysaccharides, Bacterial/immunology* | - |
dc.title | Peptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Inho Park | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.contributor.googleauthor | Jeon Soo Shin | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.identifier.doi | 10.3349/ymj.2004.45.4.755 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 15344223 | - |
dc.subject.keyword | Neisseria meningitidis | - |
dc.subject.keyword | peptide mimotope | - |
dc.subject.keyword | phage display | - |
dc.subject.keyword | vaccine | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Park, Inho | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 755 | - |
dc.citation.endPage | 758 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.45(4) : 755-758, 2004 | - |
dc.identifier.rimsid | 56234 | - |
dc.type.rims | ART | - |
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