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Peptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide

DC Field Value Language
dc.contributor.author김세종-
dc.contributor.author박인호-
dc.contributor.author신전수-
dc.contributor.author최인홍-
dc.date.accessioned2015-07-14T17:15:27Z-
dc.date.available2015-07-14T17:15:27Z-
dc.date.issued2004-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112521-
dc.description.abstractThe antigenic similarity between Neisseria meningitidis group B (NMGB) capsular polysaccharide (PS) and human polysialic acid (PSA) has hampered the development of a NMGB PS-based vaccine. But the possibility of a safe vaccine based on NMGB PS has been demonstrated by the existence of the NMGB PS-associated nonautoreactive epitope, which is distinct from those present on human PSA. To obtain peptide mimotopes of NMGB PS, we used HmenB3, a protective and nonautoreactive monoclonal antibody, to screen a phage library with 12 amino acids. We obtained 23 phage clones that bound to HmenB3 but not in the presence of E. coli K1 PS [which is α(2-8) -linked PSA like NMGB PS]. The clones contained 3 mimotopes and differed from previously described NMGB PS mimotopes. Immunization with a synthetic peptide of one mimotope elicited anti-NMGB antibodies in BALB/c mice. These mimotopes may be useful in the development of group B meningococcal vaccines.-
dc.description.statementOfResponsibilityopen-
dc.format.extent755~758-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAnimals-
dc.subject.MESHBacterial Vaccines/immunology*-
dc.subject.MESHCloning, Molecular-
dc.subject.MESHFemale-
dc.subject.MESHMeningococcal Infections/immunology*-
dc.subject.MESHMeningococcal Infections/prevention & control*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHNeisseria meningitidis, Serogroup B/genetics-
dc.subject.MESHNeisseria meningitidis, Serogroup B/immunology*-
dc.subject.MESHPolysaccharides, Bacterial/genetics-
dc.subject.MESHPolysaccharides, Bacterial/immunology*-
dc.titlePeptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorInho Park-
dc.contributor.googleauthorIn Hong Choi-
dc.contributor.googleauthorJeon Soo Shin-
dc.contributor.googleauthorSe Jong Kim-
dc.identifier.doi10.3349/ymj.2004.45.4.755-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid15344223-
dc.subject.keywordNeisseria meningitidis-
dc.subject.keywordpeptide mimotope-
dc.subject.keywordphage display-
dc.subject.keywordvaccine-
dc.contributor.alternativeNameKim, Se Jong-
dc.contributor.alternativeNamePark, Inho-
dc.contributor.alternativeNameShin, Jeon Soo-
dc.contributor.alternativeNameChoi, In Hong-
dc.rights.accessRightsfree-
dc.citation.volume45-
dc.citation.number4-
dc.citation.startPage755-
dc.citation.endPage758-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.45(4) : 755-758, 2004-
dc.identifier.rimsid56234-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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