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Effects of continuous and interrupted orthodontic force on interleukin-1β and prostaglandin E2 production in gingival crevicular fluid

Authors
 Kee-Joon Lee  ;  Young-Chel Park  ;  Yun-Jung Yoo  ;  Seong-Ho Choi  ;  Hyung-Seog Yu 
Citation
 AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, Vol.125(2) : 168-177, 2004 
Journal Title
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
ISSN
 0889-5406 
Issue Date
2004
MeSH
Adolescent ; Adult ; Analysis of Variance ; Bicuspid/surgery ; Cuspid/physiopathology ; Dental Alloys ; Dinoprostone/analysis* ; Dinoprostone/metabolism ; Feedback ; Female ; Follow-Up Studies ; Gingival Crevicular Fluid/chemistry* ; Humans ; Interleukin-1/analysis* ; Interleukin-1/metabolism ; Male ; Nickel ; Orthodontic Wires ; Serial Extraction ; Stress, Mechanical ; Time Factors ; Titanium ; Tooth Movement Techniques/instrumentation ; Tooth Movement Techniques/methods* ; Up-Regulation
Abstract
The purpose of this study was to evaluate the effects of a light continuous force and an interrupted force with weekly reactivation on interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)); possible interactions between these 2 potent mediators of the bone resorption process were assessed in vivo. Ten healthy young adults (mean age 20.6 years, 2 men, 8 women) with 4 premolars extracted were assessed. In each subject, 1 maxillary canine (E1) received continuous force with a nickel-titanium coil spring. The opposite canine (E2) received an interrupted force with a screw-attached retractor; the force was reactivated weekly by 2 turns of the screw. An antagonistic canine was used as a control. Gingival crevicular fluid was collected from the distal side of each tooth, 10 times in 3 weeks, and IL-1beta and PGE(2) levels were measured. For E1, the IL-1beta level showed a significant elevation at 24 hours and then decreased and maintained an insignificant but high mean concentration, compared with the control site. The PGE(2) level showed a significant elevation at 24 hours and then decreased. For E2, a significant elevation of IL-1beta level was observed at 24 hours and a greater significant elevation at 24 hours after the first reactivation, compared with the control sites. The PGE(2) level increased significantly at 24 hours and remained high for 1 week. The synergistic up-regulation of PGE(2) by appliance reactivation and secreted IL-1beta was not evident with either type of force after 1 week. Both experimental sites showed significant tooth movement compared with the control sites at 3 weeks; however, there was no significant difference between the 2 experimental sites. A well-controlled mechanical stress with timely reactivation can effectively upregulate IL-1beta secretion, but there might be limitations in increasing the mediator levels, because of the feedback mechanisms in vivo. In addition, the analysis of crevicular fluid is a useful method for assessing cellular response to orthodontic force in vivo.
Full Text
http://www.sciencedirect.com/science/article/pii/S0889540603008515
DOI
10.1016/j.ajodo.2003.03.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Chel(박영철)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111676
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