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Cited 86 times in

Effects of continuous and interrupted orthodontic force on interleukin-1β and prostaglandin E2 production in gingival crevicular fluid

DC Field Value Language
dc.contributor.author박영철-
dc.contributor.author유윤정-
dc.contributor.author유형석-
dc.contributor.author이기준-
dc.contributor.author최승호-
dc.date.accessioned2015-07-14T16:49:52Z-
dc.date.available2015-07-14T16:49:52Z-
dc.date.issued2004-
dc.identifier.issn0889-5406-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111676-
dc.description.abstractThe purpose of this study was to evaluate the effects of a light continuous force and an interrupted force with weekly reactivation on interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)); possible interactions between these 2 potent mediators of the bone resorption process were assessed in vivo. Ten healthy young adults (mean age 20.6 years, 2 men, 8 women) with 4 premolars extracted were assessed. In each subject, 1 maxillary canine (E1) received continuous force with a nickel-titanium coil spring. The opposite canine (E2) received an interrupted force with a screw-attached retractor; the force was reactivated weekly by 2 turns of the screw. An antagonistic canine was used as a control. Gingival crevicular fluid was collected from the distal side of each tooth, 10 times in 3 weeks, and IL-1beta and PGE(2) levels were measured. For E1, the IL-1beta level showed a significant elevation at 24 hours and then decreased and maintained an insignificant but high mean concentration, compared with the control site. The PGE(2) level showed a significant elevation at 24 hours and then decreased. For E2, a significant elevation of IL-1beta level was observed at 24 hours and a greater significant elevation at 24 hours after the first reactivation, compared with the control sites. The PGE(2) level increased significantly at 24 hours and remained high for 1 week. The synergistic up-regulation of PGE(2) by appliance reactivation and secreted IL-1beta was not evident with either type of force after 1 week. Both experimental sites showed significant tooth movement compared with the control sites at 3 weeks; however, there was no significant difference between the 2 experimental sites. A well-controlled mechanical stress with timely reactivation can effectively upregulate IL-1beta secretion, but there might be limitations in increasing the mediator levels, because of the feedback mechanisms in vivo. In addition, the analysis of crevicular fluid is a useful method for assessing cellular response to orthodontic force in vivo.-
dc.description.statementOfResponsibilityopen-
dc.format.extent168~177-
dc.relation.isPartOfAMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHBicuspid/surgery-
dc.subject.MESHCuspid/physiopathology-
dc.subject.MESHDental Alloys-
dc.subject.MESHDinoprostone/analysis*-
dc.subject.MESHDinoprostone/metabolism-
dc.subject.MESHFeedback-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGingival Crevicular Fluid/chemistry*-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-1/analysis*-
dc.subject.MESHInterleukin-1/metabolism-
dc.subject.MESHMale-
dc.subject.MESHNickel-
dc.subject.MESHOrthodontic Wires-
dc.subject.MESHSerial Extraction-
dc.subject.MESHStress, Mechanical-
dc.subject.MESHTime Factors-
dc.subject.MESHTitanium-
dc.subject.MESHTooth Movement Techniques/instrumentation-
dc.subject.MESHTooth Movement Techniques/methods*-
dc.subject.MESHUp-Regulation-
dc.titleEffects of continuous and interrupted orthodontic force on interleukin-1β and prostaglandin E2 production in gingival crevicular fluid-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorKee-Joon Lee-
dc.contributor.googleauthorYoung-Chel Park-
dc.contributor.googleauthorYun-Jung Yoo-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorHyung-Seog Yu-
dc.identifier.doi10.1016/j.ajodo.2003.03.006-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ00098-
dc.identifier.eissn1097-6752-
dc.identifier.pmid14765054-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0889540603008515-
dc.contributor.alternativeNamePark, Young Chel-
dc.contributor.alternativeNameYoo, Yun Jung-
dc.contributor.alternativeNameYu, Hyung Seog-
dc.contributor.alternativeNameLee, Kee Joon-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.rights.accessRightsnot free-
dc.citation.volume125-
dc.citation.number2-
dc.citation.startPage168-
dc.citation.endPage177-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, Vol.125(2) : 168-177, 2004-
dc.identifier.rimsid37405-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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