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Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae

Authors
 Ju Ho Youn  ;  Han-Jeong Myung  ;  Jeon-Soo Shin  ;  Sang-Nae Cho  ;  In-Hong Choi  ;  Patrick J. Brennan  ;  Delphi Chatterjee  ;  Abraham Liav 
Citation
 FEMS Immunology & Medical Microbiology, Vol.41(1) : 51-57, 2004 
Journal Title
 FEMS Immunology & Medical Microbiology 
ISSN
 0928-8244 
Issue Date
2004
Abstract
Phenolic glycolipid-I (PGL-I), a Mycobacterium leprae-specific antigen, has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy. In an effort to produce an alternate antigen of PGL-I, the mimotope peptides of PGL-I, W(T/R)LGPY(V/M), were obtained using a monoclonal antibody, III603.8, specific to PGL-I by a phage library. The biotin-labeled predominant mimotope peptide of PGLP1, WTLGPYV, bound to III603.8 in a dose-dependent manner in an immunoassay. However, PGLP1 did not bind to anti-PGL-I antibodies in the serum samples from leprosy patients that were reactive to PGL-I. Although the mimotope peptide of WTLGPYV was not effective as an alternate antigen of PGL-I for the serodiagnosis of leprosy, but it would be of interest to know how the mimotope peptides mimic the role of PGL-I antigen in the pathogenesis of M. leprae infection.
Full Text
http://onlinelibrary.wiley.com/doi/10.1016/j.femsim.2004.01.001/abstract
DOI
10.1016/j.femsim.2004.01.001
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
명한정(Myung, Han Jeong)
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
윤주호(Youn, Ju Ho)
조상래(Cho, Sang Nae)
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111331
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