Cited 11 times in
Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae
DC Field | Value | Language |
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dc.contributor.author | 명한정 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 윤주호 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-07-14T16:39:33Z | - |
dc.date.available | 2015-07-14T16:39:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0928-8244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111331 | - |
dc.description.abstract | Phenolic glycolipid-I (PGL-I), a Mycobacterium leprae-specific antigen, has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy. In an effort to produce an alternate antigen of PGL-I, the mimotope peptides of PGL-I, W(T/R)LGPY(V/M), were obtained using a monoclonal antibody, III603.8, specific to PGL-I by a phage library. The biotin-labeled predominant mimotope peptide of PGLP1, WTLGPYV, bound to III603.8 in a dose-dependent manner in an immunoassay. However, PGLP1 did not bind to anti-PGL-I antibodies in the serum samples from leprosy patients that were reactive to PGL-I. Although the mimotope peptide of WTLGPYV was not effective as an alternate antigen of PGL-I for the serodiagnosis of leprosy, but it would be of interest to know how the mimotope peptides mimic the role of PGL-I antigen in the pathogenesis of M. leprae infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 51~57 | - |
dc.relation.isPartOf | FEMS Immunology & Medical Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Ju Ho Youn | - |
dc.contributor.googleauthor | Han-Jeong Myung | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.contributor.googleauthor | Patrick J. Brennan | - |
dc.contributor.googleauthor | Delphi Chatterjee | - |
dc.contributor.googleauthor | Abraham Liav | - |
dc.identifier.doi | 10.1016/j.femsim.2004.01.001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00891 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1016/j.femsim.2004.01.001/abstract | - |
dc.subject.keyword | Leprosy | - |
dc.subject.keyword | Phenolic glycolipid‐I | - |
dc.subject.keyword | Mimotope | - |
dc.subject.keyword | Serodiagnosis | - |
dc.contributor.alternativeName | Myung, Han Jeong | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Youn, Ju Ho | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 51 | - |
dc.citation.endPage | 57 | - |
dc.identifier.bibliographicCitation | FEMS Immunology & Medical Microbiology, Vol.41(1) : 51-57, 2004 | - |
dc.identifier.rimsid | 35982 | - |
dc.type.rims | ART | - |
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