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Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae

DC FieldValueLanguage
dc.contributor.author명한정-
dc.contributor.author신전수-
dc.contributor.author윤주호-
dc.contributor.author조상래-
dc.contributor.author최인홍-
dc.date.accessioned2015-07-14T16:39:33Z-
dc.date.available2015-07-14T16:39:33Z-
dc.date.issued2004-
dc.identifier.issn0928-8244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111331-
dc.description.abstractPhenolic glycolipid-I (PGL-I), a Mycobacterium leprae-specific antigen, has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy. In an effort to produce an alternate antigen of PGL-I, the mimotope peptides of PGL-I, W(T/R)LGPY(V/M), were obtained using a monoclonal antibody, III603.8, specific to PGL-I by a phage library. The biotin-labeled predominant mimotope peptide of PGLP1, WTLGPYV, bound to III603.8 in a dose-dependent manner in an immunoassay. However, PGLP1 did not bind to anti-PGL-I antibodies in the serum samples from leprosy patients that were reactive to PGL-I. Although the mimotope peptide of WTLGPYV was not effective as an alternate antigen of PGL-I for the serodiagnosis of leprosy, but it would be of interest to know how the mimotope peptides mimic the role of PGL-I antigen in the pathogenesis of M. leprae infection.-
dc.description.statementOfResponsibilityopen-
dc.format.extent51~57-
dc.relation.isPartOfFEMS Immunology & Medical Microbiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProduction and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorJu Ho Youn-
dc.contributor.googleauthorHan-Jeong Myung-
dc.contributor.googleauthorJeon-Soo Shin-
dc.contributor.googleauthorSang-Nae Cho-
dc.contributor.googleauthorIn-Hong Choi-
dc.contributor.googleauthorPatrick J. Brennan-
dc.contributor.googleauthorDelphi Chatterjee-
dc.contributor.googleauthorAbraham Liav-
dc.identifier.doi10.1016/j.femsim.2004.01.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ00891-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1016/j.femsim.2004.01.001/abstract-
dc.subject.keywordLeprosy-
dc.subject.keywordPhenolic glycolipid‐I-
dc.subject.keywordMimotope-
dc.subject.keywordSerodiagnosis-
dc.contributor.alternativeNameMyung, Han Jeong-
dc.contributor.alternativeNameShin, Jeon Soo-
dc.contributor.alternativeNameYoun, Ju Ho-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.alternativeNameChoi, In Hong-
dc.rights.accessRightsnot free-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage57-
dc.identifier.bibliographicCitationFEMS Immunology & Medical Microbiology, Vol.41(1) : 51-57, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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