Anisotropy ; Brain Mapping* ; Child ; Child, Preschool ; Diffusion Magnetic Resonance Imaging* ; Female ; Humans ; Image Processing, Computer-Assisted/methods* ; Language Disorders/diagnosis* ; Male
Keywords
children ; di¡usion tensor imaging ; language impairment
Abstract
We evaluated the integrity of the white matter tract using diffusion-tensor magnetic resonance imaging in children with language impairments who exhibited a structurally normal brain on conventional magnetic resonance imaging, and compared it with age-matched normal children. After generating fractional anisotropy and color-coded vector maps, fractional anisotropy values of the major white matter tracts were measured in six locations and compared between the two groups. Compared with the normal control group, the fractional anisotropy values of children with language impairments showed a statistically significant reduction in the genu of the corpus callosum, which is rarely revealed on conventional magnetic resonance images. Our results suggest that delayed maturation of the white matter plays a partial role in the pathophysiological mechanisms of language impairments.