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Prediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction: Comparison with Contrast-enhanced Magnetic Resonance Imaging

Authors
 Eui-Young Choi  ;  Hye-Sun Seo  ;  Sungha Park  ;  Hyun-Joo Kim  ;  Jeong-Ah Ahn  ;  Young-Guk Ko  ;  Byoung-Wook Choi  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Jong-Won Ha  ;  Se-Joong Rim  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol.19(10) : 1211-1219, 2006 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 
ISSN
 0894-7317 
Issue Date
2006
MeSH
Blood Flow Velocity ; Blood Volume* ; Contrast Media ; Coronary Circulation* ; Echocardiography/methods* ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Myocardial Infarction/classification ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis* ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index* ; Ventricular Dysfunction, Left/classification ; Ventricular Dysfunction, Left/diagnosis* ; Ventricular Dysfunction, Left/etiology
Abstract
BACKGROUND: We sought to determine the accuracy of myocardial contrast echocardiography (MCE)-derived index of myocardial blood flow and myocardial blood volume fraction (MBVF) in predicting transmural extent of infarction and wall-motion recovery. METHODS: Low and high mechanical index MCE and contrast-enhanced magnetic resonance imaging were performed 5 to 7 days after successful percutaneous revascularization in 30 patients with acute myocardial infarction and regional wall-motion change was assessed 3 months later. The index of myocardial blood flow was calculated as A x beta (dB/s) using the equation y = A (1 - e(-beta t)), which fits the replenishment curve of low mechanical index MCE. The MBVF (mL/100 g myocardium) was calculated as 100 x 10(relative contrast intensity [CI]/10), using the relative CI by subtracting the cavity CI from the adjacent transmural CI using high mechanical index MCE. The contrast-enhanced magnetic resonance imaging-derived transmural extent of delayed hyperenhancement (DE) in 16 segments were measured and compared with corresponding MCE data. RESULTS: Among 480 segments, 382 measurable segments were subdivided into 5 groups as follows: no DE, 1% to 25% DE, 26% to 50% DE, 51% to 75% DE, and 76% to 100% DE. An increment of the extent of DE was significantly related to a decrement of A x beta (P < .001) and MBVF (P < .001). The optimal cut-off MBVF for predicting greater than 50% DE was 1.92 mL (sensitivity 82%, specificity 73%, P < .01), and persistently dysfunctional motion was 1.81 mL (sensitivity 74%, specificity 75%, P < .01). CONCLUSION: The MCE-derived A x beta and MBVF can be effective predictors of transmural extent of infarction and wall-motion recovery in the reperfused acute myocardial infarction.
Full Text
http://www.sciencedirect.com/science/article/pii/S0894731706004780
DOI
10.1016/j.echo.2006.04.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109735
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