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Shape deformation of the insula in schizophrenia

Authors
 Dong-Pyo Jang  ;  Jae-Jin Kim  ;  Tae-Sub Chung  ;  Suk Kyoon An  ;  Young Chul Jung  ;  Jun-Kee Lee  ;  Jong-Min Lee  ;  In-Young Kim  ;  Sun I. Kim 
Citation
 NEUROIMAGE, Vol.32(1) : 220-227, 2006 
Journal Title
 NEUROIMAGE 
ISSN
 1053-8119 
Issue Date
2006
MeSH
Adult ; Cerebral Cortex/anatomy & histology* ; Cerebral Cortex/pathology* ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Occipital Lobe/pathology ; Parietal Lobe/pathology ; Prefrontal Cortex/pathology ; Reference Values ; Schizophrenia/pathology* ; Temporal Lobe/pathology
Keywords
Schizophrenia ; Insula ; MRI ; Shape analysis
Abstract
Schizophrenia has been conceptualized to be a neurodevelopmental disorder. Neuroimaging evidence was generally findings of volumetric reductions in various brain structures. The shape analysis of the insula can uncover unique structural deformity in the neurodevelopmental disorder, which cannot be revealed from a simple volume measurement. The objective of this study was to demonstrate a subtle change of the insula in schizophrenia using our special shape analysis technique. Subjects were 23 patients with schizophrenia and 23 normal healthy subjects. A landmark-based structural and surface shape analysis of the insula was performed using high-spatial resolution magnetic resonance imaging. A characteristic finding was that the frontotemporal sides of the right insula were deformed in the patients with schizophrenia compared with normal controls. This deformation can be associated with abnormal development of the frontal and temporal lobes in schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S1053811906000887
DOI
10.1016/j.neuroimage.2006.01.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
Chung, Tae Sub(정태섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109194
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