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Human brain astrocytes mediate TRAIL-mediated apoptosis after treatment with IFN-γ

Authors
 Jeonggi Lee  ;  Jeong-soo Shin  ;  In-hong Choi  ;  Jeon-Soo Shin 
Citation
 Yonsei Medical Journal, Vol.47(3) : 354-358, 2006 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2006
Abstract
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1β, TNF-α or IFN-γ, TRAIL was induced in cultured fetal astrocytes. In particular, IFN-γ induced the highest levels of TRAIL in cultured astrocytes. When astrocytes were prereated with IFN-γ, they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-γ modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
Files in This Item:
T200600333.pdf Download
DOI
10.3349/ymj.2006.47.3.354
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
신전수(Shin, Jeon Soo) ORCID logo https://orcid.org/0000-0002-8294-3234
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109141
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