Cited 7 times in
Human brain astrocytes mediate TRAIL-mediated apoptosis after treatment with IFN-γ
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신전수 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-06-10T12:04:24Z | - |
dc.date.available | 2015-06-10T12:04:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109141 | - |
dc.description.abstract | TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1β, TNF-α or IFN-γ, TRAIL was induced in cultured fetal astrocytes. In particular, IFN-γ induced the highest levels of TRAIL in cultured astrocytes. When astrocytes were prereated with IFN-γ, they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-γ modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 354~358 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/genetics | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/metabolism* | - |
dc.subject.MESH | Astrocytes/cytology* | - |
dc.subject.MESH | Astrocytes/drug effects | - |
dc.subject.MESH | Astrocytes/metabolism | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/pharmacology* | - |
dc.subject.MESH | Membrane Glycoproteins/genetics | - |
dc.subject.MESH | Membrane Glycoproteins/metabolism* | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism* | - |
dc.title | Human brain astrocytes mediate TRAIL-mediated apoptosis after treatment with IFN-γ | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jeonggi Lee | - |
dc.contributor.googleauthor | Jeong-soo Shin | - |
dc.contributor.googleauthor | In-hong Choi | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.identifier.doi | 10.3349/ymj.2006.47.3.354 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16807984 | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | astrocyte | - |
dc.subject.keyword | TRAIL | - |
dc.subject.keyword | apoptosis | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 354 | - |
dc.citation.endPage | 358 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(3) : 354-358, 2006 | - |
dc.identifier.rimsid | 50616 | - |
dc.type.rims | ART | - |
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