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Cyclosporine A에 의한 치은과증식의 형태학적 특성과 기전 및 치료

Other Titles
 The Characteristics and the Mechanism of Cyclosporine A InducedGingival Overgrowth : How Can it be Treated? 
 박정철  ;  백정원  ;  노현수  ;  정의원  ;  조규성  ;  김종관  ;  최성호 
 Biomaterials Research (생체재료학회지), Vol.12(2) : 52-57, 2008 
Journal Title
 Biomaterials Research (생체재료학회지) 
Issue Date
Cyclosporine A ; Gingival overgrowth ; Gingival hyperplasia ; Azithromycin
Purpose: Cyclosporine A is an immunosuppressant drug that is widely used to reduce mortality and morbidity from graft-versus-host disease. Gingival overgrowth is a common adverse effect caused by cyclosporine A. However, the exact mechanism is not fully elucidated. The aim of this study is to understand the mechanism, clinical/histological characteris of cyclosporine A induced gingival overgrowth and the treatment. Material and Methods: Four journals on cyclosporine A induced gingival overgrowth were published from the Department of Periodontology, College of Dentistry, Yonsei University from 2000 to 2003. The authors reviewed these articles systematically to answer the following question: “What is the mechanism and characteristics of cylosporine A induced gingival overgrowth? And how can it be treated?” Results: Histological, in vivo, in vitro and Azithromycin administration analysis were performed to elucidate the histological characteristics, mechanism of gingival enlargement and proper treatment options. Conclusion: The cause of gingival overgrowth is multifactorial including administration of Cyclosporine A, gingival inflammation and genetic disposition. In histological view, increased amount of extracellular matrix, a number of fibroblasts and multilayered epithelial layer were observed. Cyclosporine A prevents influx of Ca2+ ions and inhibit phagocytosis of collagen to reduce collagen degradation. Maintaining of oral hygiene and regular check up should be encouraged. And surgical excision is considered as a treatment of choice. However, Cyclosporine A induced gingival overgrowth is a condition of collagen accumulation that can be treated by Azithromycin therapy.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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