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Cyclosporine A에 의한 치은과증식의 형태학적 특성과 기전 및 치료
DC Field | Value | Language |
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dc.contributor.author | 정의원 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.contributor.author | 김종관 | - |
dc.date.accessioned | 2015-05-19T17:26:58Z | - |
dc.date.available | 2015-05-19T17:26:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1226-4601 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108168 | - |
dc.description.abstract | Purpose: Cyclosporine A is an immunosuppressant drug that is widely used to reduce mortality and morbidity from graft-versus-host disease. Gingival overgrowth is a common adverse effect caused by cyclosporine A. However, the exact mechanism is not fully elucidated. The aim of this study is to understand the mechanism, clinical/histological characteris of cyclosporine A induced gingival overgrowth and the treatment. Material and Methods: Four journals on cyclosporine A induced gingival overgrowth were published from the Department of Periodontology, College of Dentistry, Yonsei University from 2000 to 2003. The authors reviewed these articles systematically to answer the following question: “What is the mechanism and characteristics of cylosporine A induced gingival overgrowth? And how can it be treated?” Results: Histological, in vivo, in vitro and Azithromycin administration analysis were performed to elucidate the histological characteristics, mechanism of gingival enlargement and proper treatment options. Conclusion: The cause of gingival overgrowth is multifactorial including administration of Cyclosporine A, gingival inflammation and genetic disposition. In histological view, increased amount of extracellular matrix, a number of fibroblasts and multilayered epithelial layer were observed. Cyclosporine A prevents influx of Ca2+ ions and inhibit phagocytosis of collagen to reduce collagen degradation. Maintaining of oral hygiene and regular check up should be encouraged. And surgical excision is considered as a treatment of choice. However, Cyclosporine A induced gingival overgrowth is a condition of collagen accumulation that can be treated by Azithromycin therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 52~57 | - |
dc.relation.isPartOf | Biomaterials Research (생체재료학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Cyclosporine A에 의한 치은과증식의 형태학적 특성과 기전 및 치료 | - |
dc.title.alternative | The Characteristics and the Mechanism of Cyclosporine A InducedGingival Overgrowth : How Can it be Treated? | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | 박정철 | - |
dc.contributor.googleauthor | 백정원 | - |
dc.contributor.googleauthor | 노현수 | - |
dc.contributor.googleauthor | 정의원 | - |
dc.contributor.googleauthor | 조규성 | - |
dc.contributor.googleauthor | 김종관 | - |
dc.contributor.googleauthor | 최성호 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A00914 | - |
dc.relation.journalcode | J00314 | - |
dc.identifier.pmid | Cyclosporine A; Gingival overgrowth; Gingival hyperplasia; Azithromycin | - |
dc.subject.keyword | Cyclosporine A | - |
dc.subject.keyword | Gingival overgrowth | - |
dc.subject.keyword | Gingival hyperplasia | - |
dc.subject.keyword | Azithromycin | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 57 | - |
dc.identifier.bibliographicCitation | Biomaterials Research (생체재료학회지), Vol.12(2) : 52-57, 2008 | - |
dc.identifier.rimsid | 35228 | - |
dc.type.rims | ART | - |
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