Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

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Authors: Jaemoon Yang ; Eun-Kyung Lim ; Hong Jae Lee ; Joseph Park ; Sang Cheon Lee ; Kwangyeol Lee ; Ho-Geun Yoon ; Jin-Suck Suh ; Yong-Min Huh ; Seungjoo Haam

MeSH: Antibodies, Monoclonal* ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Epithelial Cells/pathology* ; ErbB Receptors ; Flow Cytometry ; Fluorescent Dyes* ; Humans ; Magnetic Resonance Imaging ; Microscopy, Fluorescence ; Nanoparticles* ; Polyesters/chemical synthesis ; Polymethacrylic Acids/chemical synthesis ; Pyrenes/chemical synthesis

Keywords: Antibodies, Monoclonal* ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Epithelial Cells/pathology* ; ErbB Receptors ; Flow Cytometry ; Fluorescent Dyes* ; Humans ; Magnetic Resonance Imaging ; Microscopy, Fluorescence ; Nanoparticles* ; Polyesters/chemical synthesis ; Polymethacrylic Acids/chemical synthesis ; Pyrenes/chemical synthesis

Abstract: Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Full Text: http://www.sciencedirect.com/science/article/pii/S0142961207010708

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Suh, Jin Suck(서진석) https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) https://orcid.org/0000-0002-9831-4475

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