1 289

Cited 87 times in

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Authors
 Jaemoon Yang  ;  Eun-Kyung Lim  ;  Hong Jae Lee  ;  Joseph Park  ;  Sang Cheon Lee  ;  Kwangyeol Lee  ;  Ho-Geun Yoon  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 BIOMATERIALS, Vol.29(16) : 2548-2555, 2008 
Journal Title
 BIOMATERIALS 
ISSN
 0142-9612 
Issue Date
2008
MeSH
Antibodies, Monoclonal* ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Epithelial Cells/pathology* ; ErbB Receptors ; Flow Cytometry ; Fluorescent Dyes* ; Humans ; Magnetic Resonance Imaging ; Microscopy, Fluorescence ; Nanoparticles* ; Polyesters/chemical synthesis ; Polymethacrylic Acids/chemical synthesis ; Pyrenes/chemical synthesis
Keywords
Antibodies, Monoclonal* ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Epithelial Cells/pathology* ; ErbB Receptors ; Flow Cytometry ; Fluorescent Dyes* ; Humans ; Magnetic Resonance Imaging ; Microscopy, Fluorescence ; Nanoparticles* ; Polyesters/chemical synthesis ; Polymethacrylic Acids/chemical synthesis ; Pyrenes/chemical synthesis
Abstract
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961207010708
DOI
10.1016/j.biomaterials.2007.12.036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108112
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse