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Enhanced chondrogenic responses of articular chondrocytes onto porous silk fibroin scaffolds treated with microwave-induced argon plasma

Authors
 Hyun Sook Baek  ;  Young Hwan Park  ;  Chang Seok Ki  ;  Jong-Chul Park  ;  Dong Kyun Rah 
Citation
 SURFACE & COATINGS TECHNOLOGY, Vol.202(22-23) : 5794-5797, 2008 
Journal Title
 SURFACE & COATINGS TECHNOLOGY 
ISSN
 0257-8972 
Issue Date
2008
Keywords
Nanofibrous silk fibroin ; Microwave-induced argon plasma ; Chondrocytes ; CartilageTissue engineering
Abstract
Silk fibroin (SF) as a naturally occurring degradable fibrous protein with unique mechanical properties, excellent biocompatibility and processability has demonstrated strong potential for skeletal tissue engineering. Recent studies has mostly focused on nanofibrous SF (NSF) as a novel chondrogenic scaffold since its structure is very similar to collagen fibrous structure of natural extracellular matrix (ECM). However, less attention has been paid to the surface modification of NSF scaffolds by microwave-induced argon plasma. The present study was based on the hypothesis that plasma treatment to 3-D porous electrospun NSF scaffolds would improve cell growth, chondrogenicity and new cartilage-specific ECM formation of chondrocytes. It was found that plasma treatment could induce an essential modification of the surface of electrospun NSF scaffolds. The attachment and proliferation of human articular chondrocytes onto the surface-modified NSF scaffolds were significantly increased with a concomitant increase in the glycosaminoglycan synthesis. These results suggest that porous NSF scaffolds treated with microwave-induced plasma may be effective for enhancing the cellular behaviors and chondrogenic differentiation of chondrocytes and further be potentially used to cartilage tissue engineering
Full Text
http://www.sciencedirect.com/science/article/pii/S0257897208005574
DOI
10.1016/j.surfcoat.2008.06.154
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Rah, Dong Kyun(나동균)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107110
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