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Losartan inhibits proliferation and inflammation of vascular smooth muscle cells by modulation of uric acid transporter

 Seok Min Kang  ;  Woo Chul Chang  ;  So Yeon Lim  ;  Byeong Wook Song  ;  Hye Jung Kim  ;  Min Ji Cha  ;  Jae Won Oh  ;  Yang Soo Jang  ;  Nam Sik Chung  ;  Ki Chul Hwang 
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.5(3) : 521-527, 2008 
Journal Title
 Tissue Engineering and Regenerative Medicine  (조직공학과 재생의학) 
Issue Date
Hyperuricemia has known to be a risk factor for coronary artery disease, hypertension, and heart failure. Among angiotensin II receptor blockers(ARBs), only losartan lowers serum uric acid(UA) level compared with other ARBs. Recent studies have reported that UAcauses vascular smooth muscle cells(VSMCs) proliferation and inflammation by entering cells via a functional uric acid transporter(UAT). We investigated whether losartan could inhibit the UA-stimulated proliferative and inflammatory signaling activation by modulation of UAT in cultured rat aortic VSMCs. Following 72 hours incubation of UA, proliferation of VSMCs was increased dose-dependently. Losartan inhibited UA-stimulatedproliferation in dose-dependent manner with an IC50 value of about 1 M. Losartan attenuatedp38, ERKs activation, COX-2 expression, and MCP-1 production. Losartan significantly decreased expression of UAT in UA-stimulated VSMCs(33% reduction, p<0.05), which suggests inhibitory effect of losartan on the uptake of UA via UAT. These data provide that losartan may involve anti-inflammatory and antiproliferative activity by modulating UAT. Therefore, losartan may provide beneficial effect on vascular changes in hyperuricemic condition
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Hye Jung(김혜정)
Song, Byeong Wook(송병욱)
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Lim, So Yeon(임소연)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chang, Woo Chul(장우철)
Chung, Nam Sik(정남식)
Cha, Min Ji(차민지)
Hwang, Ki Chul(황기철)
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