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Losartan inhibits proliferation and inflammation of vascular smooth muscle cells by modulation of uric acid transporter

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author김혜정-
dc.contributor.author송병욱-
dc.contributor.author오재원-
dc.contributor.author임소연-
dc.contributor.author장양수-
dc.contributor.author장우철-
dc.contributor.author정남식-
dc.contributor.author차민지-
dc.contributor.author황기철-
dc.date.accessioned2015-05-19T16:28:53Z-
dc.date.available2015-05-19T16:28:53Z-
dc.date.issued2008-
dc.identifier.issn1738-2696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106385-
dc.description.abstractHyperuricemia has known to be a risk factor for coronary artery disease, hypertension, and heart failure. Among angiotensin II receptor blockers(ARBs), only losartan lowers serum uric acid(UA) level compared with other ARBs. Recent studies have reported that UAcauses vascular smooth muscle cells(VSMCs) proliferation and inflammation by entering cells via a functional uric acid transporter(UAT). We investigated whether losartan could inhibit the UA-stimulated proliferative and inflammatory signaling activation by modulation of UAT in cultured rat aortic VSMCs. Following 72 hours incubation of UA, proliferation of VSMCs was increased dose-dependently. Losartan inhibited UA-stimulatedproliferation in dose-dependent manner with an IC50 value of about 1 M. Losartan attenuatedp38, ERKs activation, COX-2 expression, and MCP-1 production. Losartan significantly decreased expression of UAT in UA-stimulated VSMCs(33% reduction, p<0.05), which suggests inhibitory effect of losartan on the uptake of UA via UAT. These data provide that losartan may involve anti-inflammatory and antiproliferative activity by modulating UAT. Therefore, losartan may provide beneficial effect on vascular changes in hyperuricemic condition-
dc.description.statementOfResponsibilityopen-
dc.format.extent521~527-
dc.relation.isPartOfTISSUE ENGINEERING AND REGENERATIVE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLosartan inhibits proliferation and inflammation of vascular smooth muscle cells by modulation of uric acid transporter-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentMedical Research Center (임상의학연구센터)-
dc.contributor.googleauthorSeok Min Kang-
dc.contributor.googleauthorWoo Chul Chang-
dc.contributor.googleauthorSo Yeon Lim-
dc.contributor.googleauthorByeong Wook Song-
dc.contributor.googleauthorHye Jung Kim-
dc.contributor.googleauthorMin Ji Cha-
dc.contributor.googleauthorJae Won Oh-
dc.contributor.googleauthorYang Soo Jang-
dc.contributor.googleauthorNam Sik Chung-
dc.contributor.googleauthorKi Chul Hwang-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA01178-
dc.contributor.localIdA02026-
dc.contributor.localIdA03448-
dc.contributor.localIdA03452-
dc.contributor.localIdA03585-
dc.contributor.localIdA03995-
dc.contributor.localIdA04456-
dc.contributor.localIdA02395-
dc.contributor.localIdA03373-1-
dc.relation.journalcodeJ02734-
dc.identifier.eissn2212-5469-
dc.identifier.pmidinflammation ; Losartan ; proliferation ; uric acid transport ; vascular smooth muscle cells-
dc.identifier.urlhttp://search.koreanstudies.net/journal/thesis_name.asp?tname=kiss2002&key=3118913-
dc.subject.keywordinflammation-
dc.subject.keywordLosartan-
dc.subject.keywordproliferation-
dc.subject.keyworduric acid transport-
dc.subject.keywordvascular smooth muscle cells-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKim, Hye Jung-
dc.contributor.alternativeNameSong, Byeong Wook-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.alternativeNameLim, So Yeon-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Woo Chul-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCha, Min Ji-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorKim, Hye Jung-
dc.contributor.affiliatedAuthorSong, Byeong Wook-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChang, Woo Chul-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCha, Min Ji-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorLim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume5-
dc.citation.number3-
dc.citation.startPage521-
dc.citation.endPage527-
dc.identifier.bibliographicCitationTISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(3) : 521-527, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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