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Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications

Authors
 Eun-Kyung Lim  ;  Jaemoon Yang  ;  Mee-ye Park  ;  Joseph Park  ;  Jin-Suck Suh  ;  Ho-Geun Yoon  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.64(1) : 111-117, 2008 
Journal Title
 COLLOIDS AND SURFACES B-BIOINTERFACES 
ISSN
 0927-7765 
Issue Date
2008
MeSH
Biocompatible Materials/chemical synthesis ; Biocompatible Materials/metabolism ; Drug Carriers/chemical synthesis* ; Drug Carriers/metabolism ; Fatty Acids/chemistry* ; Fatty Acids/metabolism ; Ferric Compounds/chemical synthesis ; HeLa Cells ; Humans ; Magnetics* ; Manganese Compounds/chemical synthesis ; Nanoparticles/chemistry ; Polyethylene Glycols/chemistry* ; Polyethylene Glycols/metabolism ; Polymers/chemical synthesis ; Polymers/metabolism ; Solubility ; Tetrazolium Salts/chemistry ; Thiazoles/chemistry ; Tissue Adhesions ; Water*
Keywords
Fatty acid ; Magnetic resonance image ; Magnetic nanocrystal ; Monomethoxy polyethylene glycol (mPEG) ; Magnetic complex
Abstract
We report the successful fabrication of the various types of water soluble PEGylated magnetic complexes (PMCs) for magnetism-related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in vitro model. Our results demonstrated that our PMCs possessed the potential for highly efficient magnetism-related biomedical applications such as MR image agents, drug delivery and tracking of cells.
Full Text
http://www.sciencedirect.com/science/article/pii/S0927776508000180
DOI
10.1016/j.colsurfb.2008.01.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106333
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