Cited 19 times in
Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-05-19T16:27:12Z | - |
dc.date.available | 2015-05-19T16:27:12Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106333 | - |
dc.description.abstract | We report the successful fabrication of the various types of water soluble PEGylated magnetic complexes (PMCs) for magnetism-related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in vitro model. Our results demonstrated that our PMCs possessed the potential for highly efficient magnetism-related biomedical applications such as MR image agents, drug delivery and tracking of cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 111~117 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biocompatible Materials/chemical synthesis | - |
dc.subject.MESH | Biocompatible Materials/metabolism | - |
dc.subject.MESH | Drug Carriers/chemical synthesis* | - |
dc.subject.MESH | Drug Carriers/metabolism | - |
dc.subject.MESH | Fatty Acids/chemistry* | - |
dc.subject.MESH | Fatty Acids/metabolism | - |
dc.subject.MESH | Ferric Compounds/chemical synthesis | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetics* | - |
dc.subject.MESH | Manganese Compounds/chemical synthesis | - |
dc.subject.MESH | Nanoparticles/chemistry | - |
dc.subject.MESH | Polyethylene Glycols/chemistry* | - |
dc.subject.MESH | Polyethylene Glycols/metabolism | - |
dc.subject.MESH | Polymers/chemical synthesis | - |
dc.subject.MESH | Polymers/metabolism | - |
dc.subject.MESH | Solubility | - |
dc.subject.MESH | Tetrazolium Salts/chemistry | - |
dc.subject.MESH | Thiazoles/chemistry | - |
dc.subject.MESH | Tissue Adhesions | - |
dc.subject.MESH | Water* | - |
dc.title | Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Mee-ye Park | - |
dc.contributor.googleauthor | Joseph Park | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1016/j.colsurfb.2008.01.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J00627 | - |
dc.identifier.eissn | 1873-4367 | - |
dc.identifier.pmid | 18282691 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0927776508000180 | - |
dc.subject.keyword | Fatty acid | - |
dc.subject.keyword | Magnetic resonance image | - |
dc.subject.keyword | Magnetic nanocrystal | - |
dc.subject.keyword | Monomethoxy polyethylene glycol (mPEG) | - |
dc.subject.keyword | Magnetic complex | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 64 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 117 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.64(1) : 111-117, 2008 | - |
dc.identifier.rimsid | 56359 | - |
dc.type.rims | ART | - |
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