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Erk와 retinoic acid의 제1인두궁 패터닝 조절

Other Titles
 Erk and retinoic acid signaling participate in the segregation and patterning of first arch derived maxilla and mandible 
 Eun-Ju Park  ;  Hye-Jin Tak  ;  Eun-Ha Park  ;  Jeong-Mi Baik  ;  Piao Zhengguo  ;  Sang-Hwy Lee 
 Journal of Korean Association Maxillofacial Plastic Reconstructive Surgery (대한악안면성형재건외과학회지), Vol.31(2) : 103-115, 2009 
Journal Title
 Journal of Korean Association Maxillofacial Plastic Reconstructive Surgery  (대한악안면성형재건외과학회지) 
Issue Date
In vertebrates, the face is mainly formed with neural crest derived neural crest cells by the inherent programs and the interactive environmental factors. Extracellular signaling-regulated kinase (Erk) is one of such programs to regulate the various cellular functions. And retinoic acid (RA) also plays an important role as a regulator in differentiation process at various stages of vertebrate embryogenesis. We wanted to know that the segregation as well as the patterning of maxillary and mandibular structure is greatly influenced by the maxillomandibular cleft (MMC) and the failure of this development may result in the maxillomandibular fusion (syngnathia) or other patterning related disorder. It has been well documented that the epithelium at this cleft region has significant expression of Fibroblast growth factor (Fgf)8, and it is essential for the patterning of the first arch derived structures. By the morphological, skeletal, cell proliferation and apoptotic, and hybridization analysis, we checked the effects of Erk inhibition and/or RA activation onto MMC and could observe that Erk and RA signaling is individually and synergically involved in the facial patterning in terms of FGF signaling pathway via Barx-1. So RA and Erk signaling work together for the MMC patterning and the segregation of maxillamandible by controlling the Fgf-related signaling pathways. And the abnormality in MMC brought by aberrant Fgf signaling may result in the disturbances of maxillary-mandibular segregation.
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
Yonsei Authors
박은주(Park, Eun Ju) ; 박은하(Park, Eun Ha) ; 이상휘(Lee, Sang Hwy) ; 탁혜진(Tak, Hye Jin)
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