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Erk와 retinoic acid의 제1인두궁 패터닝 조절

DC Field Value Language
dc.contributor.author박은주-
dc.contributor.author박은하-
dc.contributor.author이상휘-
dc.contributor.author탁혜진-
dc.date.accessioned2015-04-24T17:39:22Z-
dc.date.available2015-04-24T17:39:22Z-
dc.date.issued2009-
dc.identifier.issn1225-4207-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105815-
dc.description.abstractIn vertebrates, the face is mainly formed with neural crest derived neural crest cells by the inherent programs and the interactive environmental factors. Extracellular signaling-regulated kinase (Erk) is one of such programs to regulate the various cellular functions. And retinoic acid (RA) also plays an important role as a regulator in differentiation process at various stages of vertebrate embryogenesis. We wanted to know that the segregation as well as the patterning of maxillary and mandibular structure is greatly influenced by the maxillomandibular cleft (MMC) and the failure of this development may result in the maxillomandibular fusion (syngnathia) or other patterning related disorder. It has been well documented that the epithelium at this cleft region has significant expression of Fibroblast growth factor (Fgf)8, and it is essential for the patterning of the first arch derived structures. By the morphological, skeletal, cell proliferation and apoptotic, and hybridization analysis, we checked the effects of Erk inhibition and/or RA activation onto MMC and could observe that Erk and RA signaling is individually and synergically involved in the facial patterning in terms of FGF signaling pathway via Barx-1. So RA and Erk signaling work together for the MMC patterning and the segregation of maxillamandible by controlling the Fgf-related signaling pathways. And the abnormality in MMC brought by aberrant Fgf signaling may result in the disturbances of maxillary-mandibular segregation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent103~115-
dc.relation.isPartOfJournal of Korean Association Maxillofacial Plastic Reconstructive Surgery (대한악안면성형재건외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleErk와 retinoic acid의 제1인두궁 패터닝 조절-
dc.title.alternativeErk and retinoic acid signaling participate in the segregation and patterning of first arch derived maxilla and mandible-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Science Research Center (구강과학연구소)-
dc.contributor.googleauthorEun-Ju Park-
dc.contributor.googleauthorHye-Jin Tak-
dc.contributor.googleauthorEun-Ha Park-
dc.contributor.googleauthorJeong-Mi Baik-
dc.contributor.googleauthorPiao Zhengguo-
dc.contributor.googleauthorSang-Hwy Lee-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01620-
dc.contributor.localIdA02839-
dc.contributor.localIdA04238-
dc.contributor.localIdA01615-
dc.relation.journalcodeJ01499-
dc.subject.keywordErk-
dc.subject.keywordRetinoic acid-
dc.subject.keywordPatterning-
dc.subject.keywordFacial development-
dc.subject.keywordMaxillomandibular fusion-
dc.contributor.alternativeNamePark, Eun Ju-
dc.contributor.alternativeNamePark, Eun Ha-
dc.contributor.alternativeNameLee, Sang Hwy-
dc.contributor.alternativeNameTak, Hye Jin-
dc.contributor.affiliatedAuthorPark, Eun Ha-
dc.contributor.affiliatedAuthorLee, Sang Hwy-
dc.contributor.affiliatedAuthorTak, Hye Jin-
dc.contributor.affiliatedAuthorPark, Eun Ju-
dc.citation.volume31-
dc.citation.number2-
dc.citation.startPage103-
dc.citation.endPage115-
dc.identifier.bibliographicCitationJournal of Korean Association Maxillofacial Plastic Reconstructive Surgery (대한악안면성형재건외과학회지), Vol.31(2) : 103-115, 2009-
dc.identifier.rimsid49866-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Others (기타) > 1. Journal Papers
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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