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In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement

 Young Jin Kim  ;  Yong-Min Huh  ;  Kyu Ok Choe  ;  Byoung Wook Choi  ;  Eun Jeong Choi  ;  Yangsoo Jang  ;  Jae Myun Lee  ;  Jin-Suck Suh 
 International Journal of Cardiovascular Imaging, Vol.25(suppl 1) : 99-109, 2009 
Journal Title
 International Journal of Cardiovascular Imaging 
Issue Date
Animals ; Cell Movement* ; Cells, Cultured ; Contrast Media ; Dextrans ; Disease Models, Animal ; Electrocardiography ; Ferrosoferric Oxide ; Humans ; Iron ; Magnetic Resonance Imaging, Cine* ; Magnetite Nanoparticles ; Male ; Mesenchymal Stem Cell Transplantation* ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardial Infarction/surgery* ; Myocardium/pathology* ; Oxides ; Rats ; Rats, Sprague-Dawley ; Stroke Volume ; Time Factors ; Ventricular Function, Left*'
agnetic resonance imaging ; Mesenchymal stem cells ; Myocardial infarction ; Rats
To determine whether magnetic resonance imaging (MRI) can enable magnetically labeled mesenchymal stem cell (MSC) tracking and simultaneous in vivo functional data acquisition in rat models of myocardial infarction. Superparamagnetic iron oxide-laden human MSCs were injected into rat myocardium infarcted by cryoinjury 3 weeks after myocardial infarction. The control group received cell-free media injection. Before injection and for 3 months after, in vivo serial MRI was performed. Electrocardiography-gated gradient echo sequence MRI and cine MRI were performed for in vivo cell tracking and assessing cardiac function using left ventricular ejection fraction (LVEF), respectively. MRI revealed a persistent signal-void representing iron-laden MSCs until ten post-injection weeks. Serial follow-up MRI revealed that LVEF was significantly higher in the MSC injection group than in the control group. We conclude that MRI enables in vivo tracking of injected cells and evaluation of the long-term therapeutic potential of MSCs for myocardial infarction.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Choi, Yun Jung(최은정)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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