Cited 29 times in
In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영진 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최규옥 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 최은정 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-04-24T16:37:51Z | - |
dc.date.available | 2015-04-24T16:37:51Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1569-5794 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103876 | - |
dc.description.abstract | To determine whether magnetic resonance imaging (MRI) can enable magnetically labeled mesenchymal stem cell (MSC) tracking and simultaneous in vivo functional data acquisition in rat models of myocardial infarction. Superparamagnetic iron oxide-laden human MSCs were injected into rat myocardium infarcted by cryoinjury 3 weeks after myocardial infarction. The control group received cell-free media injection. Before injection and for 3 months after, in vivo serial MRI was performed. Electrocardiography-gated gradient echo sequence MRI and cine MRI were performed for in vivo cell tracking and assessing cardiac function using left ventricular ejection fraction (LVEF), respectively. MRI revealed a persistent signal-void representing iron-laden MSCs until ten post-injection weeks. Serial follow-up MRI revealed that LVEF was significantly higher in the MSC injection group than in the control group. We conclude that MRI enables in vivo tracking of injected cells and evaluation of the long-term therapeutic potential of MSCs for myocardial infarction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 99~109 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Movement* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Dextrans | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Ferrosoferric Oxide | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Iron | - |
dc.subject.MESH | Magnetic Resonance Imaging, Cine* | - |
dc.subject.MESH | Magnetite Nanoparticles | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation* | - |
dc.subject.MESH | Myocardial Infarction/pathology | - |
dc.subject.MESH | Myocardial Infarction/physiopathology | - |
dc.subject.MESH | Myocardial Infarction/surgery* | - |
dc.subject.MESH | Myocardium/pathology* | - |
dc.subject.MESH | Oxides | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stroke Volume | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Ventricular Function, Left*' | - |
dc.title | In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Kyu Ok Choe | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.contributor.googleauthor | Eun Jeong Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.identifier.doi | 10.1007/s10554-008-9407-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03071 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04042 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04157 | - |
dc.contributor.localId | A00727 | - |
dc.relation.journalcode | J01094 | - |
dc.identifier.eissn | 1875-8312 | - |
dc.identifier.pmid | 19132547 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10554-008-9407-0 | - |
dc.subject.keyword | agnetic resonance imaging | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Myocardial infarction | - |
dc.subject.keyword | Rats | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choe, Kyu Ok | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Choi, Yun Jung | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choe, Kyu Ok | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Choi, Yun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Young Jin | - |
dc.citation.volume | 25 | - |
dc.citation.number | suppl 1 | - |
dc.citation.startPage | 99 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.25(suppl 1) : 99-109, 2009 | - |
dc.identifier.rimsid | 37851 | - |
dc.type.rims | ART | - |
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