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Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients

 Do Young Kim  ;  Jong Won Choi  ;  Hye Young Chang  ;  Seung Up Kim  ;  Park Hana  ;  Yong Han Paik  ;  Ja Kyung Kim  ;  Sang Hoon Ahn  ;  Jun Yong Park  ;  Sook In Chung  ;  Kwan Sik Lee  ;  Kwang Hyub Han  ;  Chae Yoon Chon 
 HEPATO-GASTROENTEROLOGY, Vol.57(104) : 1351-1355, 2010 
Journal Title
Issue Date
Adult ; Alleles ; Chi-Square Distribution ; Female ; Genotype ; Hepatitis B/complications* ; Hepatitis B/genetics* ; Hepatitis B/immunology ; Humans ; Liver Cirrhosis/genetics* ; Liver Cirrhosis/immunology ; Liver Cirrhosis/virology* ; Male ; Middle Aged ; Polymorphism, Genetic* ; Republic of Korea ; Toll-Like Receptor2/genetics* ; Toll-Like Receptor2/immunology ; Toll-Like Receptor4/genetics* ; Toll-Like Receptor4/immunology
BACKGROUND/AIMS: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection.

METHODOLOGY: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing.

RESULTS: Mean age differed significantly between groups (group I, 34.8 +/- 11.4 years; group II 51.0 +/- 8.9 years; p < 0.001), whereas the proportion of males (80.2% vs. 73.4%, respectively; p = 0.085) and hepatitis B e antigen-positive patients (40.7% vs. 43.6%, respectively; p = 0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9 +/- 138.5 IU/L) than in group II (56.6 +/- 70.7 IU/L, p = 0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients.

CONCLUSIONS: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Park, Ha Na(박하나)
Paik, Yong Han(백용한)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chang, Hye Young(장혜영)
Chon, Chae Yoon(전재윤)
Chung, Sook In(정숙인) ORCID logo https://orcid.org/0000-0002-7915-9203
Choi, Jong Won(최종원)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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