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Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients

DC Field Value Language
dc.contributor.author최종원-
dc.contributor.author한광협-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author김자경-
dc.contributor.author박준용-
dc.contributor.author박하나-
dc.contributor.author백용한-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author장혜영-
dc.contributor.author전재윤-
dc.contributor.author정숙인-
dc.date.accessioned2015-04-23T17:45:52Z-
dc.date.available2015-04-23T17:45:52Z-
dc.date.issued2010-
dc.identifier.issn0172-6390-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103086-
dc.description.abstractBACKGROUND/AIMS: Hepatitis B virus (HBV) induces inflammatory signaling leading to progressive liver damage. Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes, which are important components of innate immunity against viral infection, have recently been described. We evaluated the association between TLR2 and TLR4 polymorphisms and the development of liver cirrhosis in Koreans with chronic HBV infection. METHODOLOGY: This study enrolled 456 Koreans with chronic HBV infection between December 2004 and October 2007; 242 with chronic hepatitis B (group I) and 214 with liver cirrhosis (group II). TLR2 and TLR4 polymorphisms were determined using direct sequencing. RESULTS: Mean age differed significantly between groups (group I, 34.8 +/- 11.4 years; group II 51.0 +/- 8.9 years; p < 0.001), whereas the proportion of males (80.2% vs. 73.4%, respectively; p = 0.085) and hepatitis B e antigen-positive patients (40.7% vs. 43.6%, respectively; p = 0.575) did not. The serum alanine aminotransferase level was significantly higher in group I (87.9 +/- 138.5 IU/L) than in group II (56.6 +/- 70.7 IU/L, p = 0.003). However, the TLR2 Arg677Trp and Arg753Gln and TLR4 Asp299Gly and Thr399Ile mutant alleles were not detected in any patients. CONCLUSIONS: The TLR2 Arg677Trp, Arg753Gln and TLR4 Asp299Gly, Thr399Ile mutant alleles were not detected in any patient, suggesting that they are very rare in the Korean population. Our results do not permit any conclusion regarding their role in the development of liver cirrhosis-
dc.description.statementOfResponsibilityopen-
dc.format.extent1351~1355-
dc.relation.isPartOfHEPATO-GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlleles-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHepatitis B/complications*-
dc.subject.MESHHepatitis B/genetics*-
dc.subject.MESHHepatitis B/immunology-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/genetics*-
dc.subject.MESHLiver Cirrhosis/immunology-
dc.subject.MESHLiver Cirrhosis/virology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHToll-Like Receptor2/genetics*-
dc.subject.MESHToll-Like Receptor2/immunology-
dc.subject.MESHToll-Like Receptor4/genetics*-
dc.subject.MESHToll-Like Receptor4/immunology-
dc.titleToll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJong Won Choi-
dc.contributor.googleauthorHye Young Chang-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorPark Hana-
dc.contributor.googleauthorYong Han Paik-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSook In Chung-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorKwang Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04268-
dc.contributor.localIdA00654-
dc.contributor.localIdA00852-
dc.contributor.localIdA01675-
dc.contributor.localIdA01727-
dc.contributor.localIdA01829-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03495-
dc.contributor.localIdA03640-
dc.contributor.localIdA03544-
dc.contributor.localIdA04185-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00984-
dc.identifier.pmid21443084-
dc.contributor.alternativeNameChoi, Jong Won-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNamePark, Ha Na-
dc.contributor.alternativeNamePaik, Yong Han-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameChang, Hye Young-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameChung, Sook In-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorPark, Ha Na-
dc.contributor.affiliatedAuthorPaik, Yong Han-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorChang, Hye Young-
dc.contributor.affiliatedAuthorChung, Sook In-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorChoi, Jong Won-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume57-
dc.citation.number104-
dc.citation.startPage1351-
dc.citation.endPage1355-
dc.identifier.bibliographicCitationHEPATO-GASTROENTEROLOGY, Vol.57(104) : 1351-1355, 2010-
dc.identifier.rimsid35676-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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