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False-positive rate of a "fourth-generation" HIV antigen/antibody combination assay in an area of low HIV prevalence.

Authors
 Sinyoung Kim  ;  Jong-Han Lee  ;  Jun Yong Choi  ;  June Myung Kim  ;  Hyon-Suk Kim 
Citation
 Clinical and Vaccine Immunology, Vol.17(10) : 1642-1644, 2010 
Journal Title
 Clinical and Vaccine Immunology 
ISSN
 1556-6811 
Issue Date
2010
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, Viral/blood* ; Child ; Child, Preschool ; False Positive Reactions* ; Female ; HIV Antibodies/blood* ; HIV Infections/diagnosis* ; HIV Infections/epidemiology ; Humans ; Immunoassay/methods ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Retrospective Studies ; Sensitivity and Specificity ; Virology/methods* ; Young Adult
Abstract
We retrospectively analyzed the performance of the Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with a situation of low HIV prevalence. The specificity and positive predictive value (PPV) were 99.78% and 31.21%, respectively. However, the specificity and PPV could increase to 99.99% and 89.70% using an arbitrary cutoff value.
Files in This Item:
T201002784.pdf Download
DOI
10.1128/CVI.00258-10
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, June Myung(김준명)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Lee, Jong Han(이종한)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101723
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