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Function analysis of mesenchymal Bcor in tooth development by using RNA interference

Authors
 Jinglei Cai  ;  Sungwook Kwak  ;  Jong-Min Lee  ;  Eun-Jung Kim  ;  Min-Jung Lee  ;  Gi-Hee Park  ;  Sung-Won Cho  ;  Han-Sung Jung 
Citation
 CELL AND TISSUE RESEARCH, Vol.341(2) : 251-258, 2010 
Journal Title
 CELL AND TISSUE RESEARCH 
ISSN
 0302-766X 
Issue Date
2010
MeSH
Animals ; Gene Expression Regulation, Developmental ; Humans ; Lentivirus/genetics ; Male ; Mesoderm/embryology* ; Mesoderm/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred ICR ; Odontogenesis*/genetics ; RNA Interference ; Repressor Proteins/antagonists & inhibitors ; Repressor Proteins/genetics ; Repressor Proteins/metabolism* ; Tooth/embryology* ; Tooth/metabolism
Keywords
Bcor ; RNA interference ; Tooth ; Dentin ; Root ; Mouse (ICR)
Abstract
Teeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated
Full Text
http://link.springer.com/article/10.1007%2Fs00441-010-0996-2
DOI
10.1007/s00441-010-0996-2
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Sung Wook(곽성욱)
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Park, Gi Hee(박지희)
Lee, Min Jung(이민정)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101394
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