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Function analysis of mesenchymal Bcor in tooth development by using RNA interference

DC Field Value Language
dc.contributor.author곽성욱-
dc.contributor.author김은정-
dc.contributor.author박지희-
dc.contributor.author이민정-
dc.contributor.author이종민-
dc.contributor.author정한성-
dc.contributor.author조성원-
dc.date.accessioned2015-04-23T16:52:34Z-
dc.date.available2015-04-23T16:52:34Z-
dc.date.issued2010-
dc.identifier.issn0302-766X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101394-
dc.description.abstractTeeth, an excellent model for studying organogenesis, develop from a series of epithelial-mesenchymal interactions that are mediated by a complex molecular network. Bcor (BCL-6 interacting corepressor) has recently been discovered, but little is known about its function in tooth development. Mutations in BCOR affect humans with oculofaciocardiodental syndrome, which is an X-linked dominant disorder with presumed male lethality and which comprises microphthalmia, congenital cataracts, radiculomegaly, and cardiac and digital abnormalities. In this study, the Bcor expression pattern has been intensively investigated during mouse molar development. Bcor is expressed in both dental epithelium and the mesenchyme at E11.5. To understand the function of Bcor, knockdown of Bcor has been examined by using lentivirus-mediated RNA interference. Silencing of Bcor expression in dental mesenchymal cells at E14.5 causes dentinogenesis defects and retardation of tooth root development. Thus, our results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. The function of Bcor expressed in the epithelium remains to be elucidated-
dc.description.statementOfResponsibilityopen-
dc.format.extent251~258-
dc.relation.isPartOfCELL AND TISSUE RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHGene Expression Regulation, Developmental-
dc.subject.MESHHumans-
dc.subject.MESHLentivirus/genetics-
dc.subject.MESHMale-
dc.subject.MESHMesoderm/embryology*-
dc.subject.MESHMesoderm/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHOdontogenesis*/genetics-
dc.subject.MESHRNA Interference-
dc.subject.MESHRepressor Proteins/antagonists & inhibitors-
dc.subject.MESHRepressor Proteins/genetics-
dc.subject.MESHRepressor Proteins/metabolism*-
dc.subject.MESHTooth/embryology*-
dc.subject.MESHTooth/metabolism-
dc.titleFunction analysis of mesenchymal Bcor in tooth development by using RNA interference-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentDept. of Periodontology, Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터)-
dc.contributor.googleauthorJinglei Cai-
dc.contributor.googleauthorSungwook Kwak-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorEun-Jung Kim-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorGi-Hee Park-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1007/s00441-010-0996-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00167-
dc.contributor.localIdA01695-
dc.contributor.localIdA03758-
dc.contributor.localIdA03837-
dc.contributor.localIdA00814-
dc.contributor.localIdA02785-
dc.contributor.localIdA04640-
dc.relation.journalcodeJ00474-
dc.identifier.eissn1432-0878-
dc.identifier.pmid20563598-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00441-010-0996-2-
dc.subject.keywordBcor-
dc.subject.keywordRNA interference-
dc.subject.keywordTooth-
dc.subject.keywordDentin-
dc.subject.keywordRoot-
dc.subject.keywordMouse (ICR)-
dc.contributor.alternativeNameKwak, Sung Wook-
dc.contributor.alternativeNameKim, Eun Jung-
dc.contributor.alternativeNamePark, Gi Hee-
dc.contributor.alternativeNameLee, Min Jung-
dc.contributor.alternativeNameLee, Jong Min-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthorKwak, Sung Wook-
dc.contributor.affiliatedAuthorPark, Gi Hee-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorKim, Eun Jung-
dc.contributor.affiliatedAuthorLee, Min Jung-
dc.contributor.affiliatedAuthorLee, Jong Min-
dc.citation.volume341-
dc.citation.number2-
dc.citation.startPage251-
dc.citation.endPage258-
dc.identifier.bibliographicCitationCELL AND TISSUE RESEARCH, Vol.341(2) : 251-258, 2010-
dc.identifier.rimsid51024-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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