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Visceral Fat Accumulation Is Associated with Colorectal Cancer in Postmenopausal Women

 Jee-Yon Lee  ;  Hye-Sun Lee  ;  Duk-Chul Lee  ;  Sang-Hui Chu  ;  Justin Y. Jeon  ;  Nam-Kyu Kim  ;  Ji-Won Lee 
 PLOS ONE, Vol.9(11) : e110587, 2014 
Journal Title
Issue Date
Aged ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology* ; Colorectal Neoplasms/pathology ; Female ; Humans ; Intra-Abdominal Fat/pathology* ; Middle Aged ; Neoplasm Staging ; Obesity/complications ; Obesity/pathology ; Odds Ratio ; Postmenopause* ; Prevalence ; Risk Factors
Obesity is a known risk factor for colorectal cancer (CRC), and emerging data suggest that this association is mediated by visceral fat rather than total body fat. However, there is a lack of studies evaluating the association between visceral fat area and the prevalence of CRC.
To investigate the relationship between visceral adiposity and prevalence of CRC, data of 497 women diagnosed with CRC and 318 apparently healthy women were analysed and data of well-balanced 191 pairs of women with CRC and healthy women matched based on propensity scores were additionally analysed. Diagnosis of CRC was confirmed by colonoscopy and histology. Metabolic parameters were assessed, along with body composition, using computed tomography.
The median visceral fat area was significantly higher in the CRC group compared with the control group before and after matching. The prevalence of CRC increased significantly with increasing visceral fat tertiles after matching (p for trend <0.01). A multivariate analysis showed that mean visceral fat area of individuals in the 67th percentile or greater group was associated with an increased prevalence of CRC (adjusted odds ratio: 1.80; 95% confidence interval: 1.12-2.91 before matching and adjusted odds ratio: 2.96; 95% confidence interval: 1.38-6.33) compared with that of individuals in the 33th percentile or lower group.
Thus, we conclude that visceral fat area is positively associated with the prevalence of CRC. Although we could not determine the causality, visceral adiposity may be associated with the risk of CRC. Further prospective studies are required to determine the benefits of controlling visceral obesity for reducing CRC risk.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
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